{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T22:34:59Z","timestamp":1774996499532,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Glaucoma incidence in patients with endogenous Cushing's syndrome (CS) has never been established. We aim to assess the risk for glaucoma among CS patients compared to controls and determine the age of disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide retrospective matched\u2010cohort study of patients with endogenous CS diagnosed between 2000 and 2023. Patients with CS were matched in a 1:5 ratio, with a control group individually matched for age, sex, socioeconomic status and body mass index. Main outcomes were the incidence of glaucoma and disease onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 609 patients [396 women (65%); mean age 48.1\u2009\u00b1\u200917\u2009years] were included in the CS group and 3018 controls. Follow\u2010up duration was 14.6\u2009years (IQR 9.8\u201320.2) for the study group. The aetiology of hypercortisolism was divided into pituitary (259, 42.6%), adrenal (206, 33.8%) and unconfirmed aetiology (144, 23.6%) patients. At baseline, 44 (7.2%) CS patients had a diagnosis of glaucoma, compared with 151 (5%) controls. The overall risk for glaucoma was 74% higher in patients with CS compared with matched controls (hazard ratio\u2009=\u20091.74, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Patients with CS who developed glaucoma were younger (mean age of 62\u2009\u00b1\u200914.7\u2009years) than controls (mean age of 66\u2009\u00b1\u200911.3\u2009years), (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) [Correction added on 1 February 2025, after first online publication: The mean age has been corrected in the preceding sentence]. The overall risk for glaucoma in CS was high for both patients in remission and patients with persistent hypercortisolism (<jats:italic>p<\/jats:italic>\u2009=\u20090.048). Patients with active hypercortisolism experienced an earlier glaucoma onset (82.1\u2009\u00b1\u200988.0\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endogenous CS is associated with increased risk for glaucoma regardless of remission status and develops at a younger age compared with the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16787","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T09:13:41Z","timestamp":1730798021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher risk and earlier onset glaucoma in Cushing's syndrome"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-218X","authenticated-orcid":false,"given":"Yael","family":"Sharon","sequence":"first","affiliation":[{"name":"Ophthalmology Department Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzipora","family":"Shochat","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Rabin Medical Center Beilinson Hospital  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Rudman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Endocrinology Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Research Authority Rabin Medical Center, Beilinson Hospital  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-5253","authenticated-orcid":false,"given":"Alon","family":"Zahavi","sequence":"additional","affiliation":[{"name":"Ophthalmology Department Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Laboratory of eye Research Felsenstein Medical Research Center  Petach Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilan","family":"Shimon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Endocrinology Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Fleseriu","sequence":"additional","affiliation":[{"name":"Pituitary Center, Departments of Medicine and Neurological Surgery Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Akirov","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Institute of Endocrinology Beilinson Hospital, Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"198","article-title":"Intraocular Pressure Response to Topical Corticosteroids","volume":"4","author":"Becker B.","year":"1965","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00052-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.03.063"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00235-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.122.4.532"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01961-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31829521f2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(74)90238-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00075-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00927251"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701895"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.04.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.04.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002113"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_684_15"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12202452"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10028-1226"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.11305"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz136"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4158\/ACCR-2019-0097"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2014.01.018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102972"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T06:53:59Z","timestamp":1744354439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/aos.16787"],"URL":"https:\/\/doi.org\/10.1111\/aos.16787","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"2024-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}