{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:24:06Z","timestamp":1790871846101,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006251","name":"Universit\u00e9 de Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR 2010\u2010PRSP\u2010011 VISA"],"award-info":[{"award-number":["ANR 2010\u2010PRSP\u2010011 VISA"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013121","name":"Fondation Voir et Entendre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Cataract, the leading cause of blindness worldwide, is a multifactorial disease involving oxidative stress mechanisms. The aim of our study was to investigate the relationship between air pollution exposure and the incidence of cataract surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 3C\u2010Alienor study is a population\u2010based cohort of residents of Bordeaux, France, aged 65\u2009years or more, recruited in 1999\u20132000 and followed every 2\u20133\u2009years until 2017. Cataract surgery was self\u2010reported and checked at slit\u2010lamp by trained professionals. Average air pollution exposure (particulate matter \u22642.5 \u03bcm (PM<jats:sub>2.5<\/jats:sub>), black carbon (BC), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>)) in the 10\u2009years preceding baseline was estimated at the participants' geocoded residential address, using temporally adjusted land use regression. Associations of 10\u2010year average air pollution exposure with incidence of cataract were estimated using Cox proportional hazard models adjusted for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 829 subjects without cataract surgery prior to inclusion; the mean age at inclusion was 72.6\u2009years (standard deviation (SD): 4.2) and 61% were women. The median (Interquartile\u2010range (IQR)) follow\u2010up duration was 14.1 (6.4) years during which 507 participants underwent cataract surgery. Exposure to a concentration \u226540\u2009\u03bcg\/m<jats:sup>3<\/jats:sup> of NO<jats:sub>2<\/jats:sub> (the current regulatory limit value in Europe) was associated with incident cataract surgery (HR\u2009=\u20091.46, CI (1.16, 1.84), <jats:italic>p<\/jats:italic>\u2009=\u20090.001). No statistically significant association was found with PM<jats:sub>2.5<\/jats:sub> and BC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term exposure to a NO<jats:sub>2<\/jats:sub> concentration\u2009\u2265\u200940\u2009\u03bcg\/m<jats:sup>3<\/jats:sup> was associated with an increased incidence of cataract surgery. Complying with current European air pollution standards could reduce cataract surgery costs and improve population quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.16790","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T02:44:26Z","timestamp":1731379466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ambient air pollution exposure and incidence of cataract surgery: The prospective 3City\u2010Alienor study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-7980","authenticated-orcid":false,"given":"Laure","family":"Gayraud","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Mortamais","sequence":"additional","affiliation":[{"name":"University of Montpellier, INSERM, Institute for Neurosciences of Montpellier (INM)  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"de Hoogh","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Allschwil Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-5764","authenticated-orcid":false,"given":"Audrey","family":"Cougnard\u2010Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-9535","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Korobelnik","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3127-8617","authenticated-orcid":false,"given":"Marie\u2010Noelle","family":"Delyfer","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010B\u00e9n\u00e9dicte","family":"Rougier","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Leffondr\u00e9","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Helmer","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Vienneau","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Allschwil Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2099-0481","authenticated-orcid":false,"given":"C\u00e9cile","family":"Delcourt","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, INSERM, BPH, U1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072920"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1990.tb08679.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-1266-1"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.15.7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01839-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.07.036"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/es400156t"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14471"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-010-0131-9"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2012.08.038"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-14491-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30489-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.10.7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.9.17"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2021.1604465"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031255"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9111046"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144976"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103093"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.09.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30544-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/487074"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1110383"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027474"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091374"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5853"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17249231"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.16790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T06:54:14Z","timestamp":1744354454000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.16790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/aos.16790"],"URL":"https:\/\/doi.org\/10.1111\/aos.16790","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"2024-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}