{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:43:49Z","timestamp":1787496229959,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n To assess the impact of the ratio between photoreceptor (PR) loss and retinal pigment epithelium (RPE) loss on the progression of geographic atrophy (GA) and to explore correlations between abnormal fundus autofluorescence (FAF) patterns and the PR\u2010RPE loss ratio.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Single\u2010centre, retrospective case series.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Multimodal images from 87 treatment\u2010na\u00efve patients with GA and a follow\u2010up of 6\u201324\u2009months were included. Geographic atrophy areas on FAF images and areas of PR\u2010RPE loss on optical coherence tomography images at baseline were manually annotated, and FAF patterns were classified. The impact of these biomarkers on GA progression through month 24 as measured on FAF was evaluated using random slope and intercept models and Spearman correlation coefficients (\n \u03c1<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean square\u2010root GA growth rate was 0.27\u2009\u00b1\u20090.28\u2009mm per year. Mean PR\u2010RPE loss ratio at baseline was 2.16\u2009\u00b1\u20091.75. Fundus autofluorescence patterns \u201cdiffuse\u201d and \u201cdiffuse trickling\u201d showed higher PR\u2010RPE loss ratios at baseline and contributed statistically significantly to the slope of GA progression (\n p<\/jats:italic>\n \u2009=\u20090.01 and\n p<\/jats:italic>\n \u2009=\u20090.0019). Baseline GA lesion size was negatively correlated to PR\u2010RPE loss ratios at baseline (\n \u03c1<\/jats:italic>\n \u2009=\u2009\u22120.47,\n p<\/jats:italic>\n \u2009<\u20090.0001). Overall, GA growth was higher in patients with higher PR\u2010RPE loss ratios at baseline (\n \u03c1<\/jats:italic>\n \u2009=\u20090.35,\n p<\/jats:italic>\n \u2009=\u20090.0011), and the ratio's contribution to the slope of GA progression was statistically significant (\n p<\/jats:italic>\n \u2009=\u20090.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Eyes with higher PR\u2010RPE loss ratios were more likely to exhibit FAF patterns \u201cdiffuse\u201d and \u201cdiffuse trickling\u201d and showed higher GA progression rates. Baseline characteristics derived from FAF and OCT images may thus offer information on lesion progression.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.17431","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:35:00Z","timestamp":1734500100000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Photoreceptor\u2010\n RPE<\/scp>\n loss ratio and fundus autofluorescence patterns as predictive factors for lesion progression in geographic atrophy"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0914-0766","authenticated-orcid":false,"given":"Daniel","family":"Egger","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Landesklinikum Mistelbach\u2010G\u00e4nserndorf Mistelbach Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"},{"name":"Paracelsus Medical University Salzburg Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Doll","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Futurophta Private Practice, 27 Boulevard des Minimes Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ahmadzai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landesklinikum Mistelbach\u2010G\u00e4nserndorf Mistelbach Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina A.","family":"Heger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landesklinikum Mistelbach\u2010G\u00e4nserndorf Mistelbach Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kreid","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landesklinikum Mistelbach\u2010G\u00e4nserndorf Mistelbach Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Montuoro","sequence":"additional","affiliation":[{"name":"Software Competence Center Hagenberg GmbH Hagenberg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Link","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taffeta Chingning","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieh","family":"Esmaeelpour","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian M.","family":"Waldstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Landesklinikum Mistelbach\u2010G\u00e4nserndorf Mistelbach Austria"},{"name":"Karl Landsteiner University of Health Sciences Krems Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000361077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010021\u201001747\u2010z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.11.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.05.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17\u201022339"},{"issue":"3","key":"e_1_2_7_8_1","first-page":"718","article-title":"In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics","volume":"36","author":"Delori F.C.","year":"1995","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"7","key":"e_1_2_7_9_1","first-page":"583","article-title":"Lipofuscin and melanin of human retinal pigment epithelium. 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