{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:35:41Z","timestamp":1788417341162,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004786","name":"ODAS Stichting","doi-asserted-by":"publisher","award":["2021\u201032327"],"award-info":[{"award-number":["2021\u201032327"]}],"id":[{"id":"10.13039\/501100004786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Red blood cell (RBC) transfusions are believed to be associated with retinopathy of prematurity (ROP), but the underlying mechanism is not fully understood, partly due to the lack of information on RBC transfusion timing. The aim was to determine the association between the timing and amount of RBC transfusions and the development and severity of ROP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective dual\u2010center cohort study included 1177 neonates born in 2004\u20132022 with a gestational age at birth \u226428\u2009weeks. Primary outcomes were any stage ROP and severe ROP based on maximum staging. Phase I of ROP was defined as \u226432.0\u2009weeks postmenstrual age and phase II as &gt;32.0\u2009weeks postmenstrual age. Logistic regression analyses were adjusted for gestational age at birth, small for gestational age, mechanical ventilation duration, postnatal corticosteroids, sepsis, and necrotizing enterocolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis showed independent associations with severe ROP for RBC transfusion (OR 5.1; 95% CI 1.8\u201314.3), number of RBC transfusions (OR 1.2; 95% CI 1.1\u20131.3), RBC transfusion in phase I (OR 2.5; 95% CI 1.2\u20135.3), number of RBC transfusions in phase I (OR 1.2; 95% CI 1.0\u20131.3), RBC transfusion in phase II (OR 4.1; 95% CI 2.7\u20136.3) and number of RBC transfusions in phase II (OR 1.9; 95% CI 1.5\u20132.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on maximum ROP staging, RBC transfusions in phases I and II are both associated with a high risk of severe ROP. A randomized controlled trial is urgently needed to determine the potential effect of RBC transfusions in phase II on ROP progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17471","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:22:53Z","timestamp":1741746173000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The association between red blood cell transfusion timing and the development of retinopathy of prematurity: Application of the two\u2010phase theory"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-2256","authenticated-orcid":false,"given":"Salma","family":"El Emrani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Division of Neonatology, Department of Pediatrics Willem\u2010Alexander Children's Hospital, Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizanne A.","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Tjiam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus MC, University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"van Bohemen","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC, University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline U. M.","family":"Termote","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Women and Neonate Wilhelmina Children's Hospital, University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte E.","family":"van der Meeren","sequence":"additional","affiliation":[{"name":"Department of Pathology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Pathology Erasmus MC, University Medical Center  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irwin K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Neonatal and Pediatric Intensive Care Erasmus MC, University Medical Center\u2010Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Rob","family":"Taal","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Neonatal and Pediatric Intensive Care Erasmus MC, University Medical Center\u2010Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics Willem\u2010Alexander Children's Hospital, Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline E.","family":"Schalij\u2010Delfos","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.116403"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2020.00002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12049"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.17079"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.121.12.1684"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10690"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.16965"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-318293"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.12.023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_8_14_1","first-page":"475","article-title":"Spontaneous regression of retinopathy of prematurity: incidence and predictive factors","volume":"6","author":"Ju R.H.","year":"2013","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020248"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2022.12.13"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16918"},{"key":"e_1_2_8_18_1","article-title":"A review on the incidence and related risk factors of retinopathy of prematurity across various countries","volume":"14","author":"Nair A.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.975613"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2019.109541"},{"key":"e_1_2_8_22_1","first-page":"1341","article-title":"Iron, plasma antioxidants, and the \u2018oxygen radical disease of prematurity\u2019","volume":"142","author":"Sullivan J.L.","year":"1988","journal-title":"American Journal of Diseases of Children"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.814194"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.06.011"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15269"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303123"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)34975-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234266"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.17471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T05:03:30Z","timestamp":1754975010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.17471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/aos.17471"],"URL":"https:\/\/doi.org\/10.1111\/aos.17471","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"2024-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}