{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:30:46Z","timestamp":1767339046704,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fellow eyes (FE) of 73 keratoconus (KC) patients with acute corneal hydrops (ACH) and 130 KC patients without ACH (total 236 eyes, 110 more severely affected), serving as control groups, were retrospectively analysed to identify potential risk factors associated with the development of ACH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Tomographic (Pentacam<jats:sup>\u00ae<\/jats:sup>) and biomechanical analysis (Corvis ST<jats:sup>\u00ae<\/jats:sup>, both Oculus, Germany) were performed. Tomographic parameters are as follows: K\u2010max, thinnest corneal thickness (TCT), Belin\/Ambr\u00f3sio deviation (BAD\u2010D) and the tomographic ABCDE\u2010staging. Biomechanical analysis included Integrated Radius (IR), DA Ratio (1 and 2\u2009mm), stiffness parameter A1 (SP\u2010A1), Ambr\u00f3sio's relational thickness horizontal (ARTh), Corvis Biomechanical Index (CBI), Corvis Biomechanical Factor (CBiF) and the biomechanical E\u2010staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among ACH patients, most were males (77%), with pre\u2010existing conditions including allergies (36%), asthma (10%) and frequent eye rubbing (61%), with no significant differences to the control group (CG). The ABCDE staging showed significantly different distribution patterns, with the ACH\u2010FE predominantly showing stage B4, contrasting with a more heterogeneous distribution in both control groups. ACH\u2010FE showed significantly lower SP\u2010A1 levels than the CG (71 vs. 80 for CG all eyes, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and 71 vs. 76 for more severely affected control eyes, <jats:italic>p<\/jats:italic>\u2009=\u20090.01; Mann\u2013Whitney <jats:italic>U<\/jats:italic> test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ACH\u2010FE showed a predominant presence in stage B4, yet a heterogenic distribution in the other tomographic parameters (\u2018A\u2019|\u2018C\u2019). Lower SP\u2010A1 values suggest that these eyes may be less stiff and resistant to mechanical stress. Our results potentially indicate a histopathological weakness in the posterior cornea that could predispose one to the development of ACH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17474","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T16:26:12Z","timestamp":1741364772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is there a predisposition for developing corneal hydrops in keratoconus?\u2014Tomographic and biomechanical analysis of the fellow eyes"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1227-7819","authenticated-orcid":false,"given":"Vesna","family":"Bosic","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Saarland University Medical Center  Homburg 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