{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:53:39Z","timestamp":1787727219440,"version":"build-2784847793"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (\n                      <jats:italic>K<\/jats:italic>\n                      ) using ultra\u2010wide\u2010field optical coherence tomography angiography (UWF\u2010OCTA).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited. Highest\n                      <jats:italic>K<\/jats:italic>\n                      values (\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      ) and choroidal parameters\u2014vessel flow density (VFD), choroidal vascularity volume (CVV) and index (CVI), thickness, and volume\u2014were compared in central and peripheral regions, and the fovea\u2010centered 12\u2010mm ETDRS quadrants of 24\u2009\u00d7\u200920\u2009mm UWF\u2010OCTA images. Associations between choroidal parameters and\n                      <jats:italic>K<\/jats:italic>\n                      values in Type I PS eyes were analysed using multiple linear regression analysis, controlling for the confounding effect of AL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Type I PS eyes showed increased\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      in various subregions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), except the 12\u2010mm ETDRS superior quadrant. CVV, choroidal thickness, and volume were higher in the peripheral region of the UWF\u2010SS\u2010OCTA image in Type I PS eyes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Central CVI and large and medium choroidal vascular layer\u2010VFD were significantly lower in Type I PS eyes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Correlation analysis revealed a negative association between macular\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      and central CVI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the peripheral region,\n                      <jats:italic>K<\/jats:italic>\n                      <jats:sub>max<\/jats:sub>\n                      showed a positive correlation with choroidal thickness and volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). These correlations were partially confirmed across several quadrants of the 12\u2010mm ETDRS grid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Type I PS eyes exhibit attenuated choroidal perfusion and a potentially reorganized choroidal structure and circulation, associated with Gaussian curvature severity. UWF\u2010OCTA shows promise for non\u2010invasive visualization of the choroidal alterations in PS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17477","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:34:41Z","timestamp":1741718081000},"page":"998-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra\u2010wide\u2010field optical coherence tomography angiography"],"prefix":"10.1111","volume":"103","author":[{"given":"Qing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing 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