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For a reliable imaging of lesions in these early stages, optical coherence tomography (OCT) turned out to be largely preferable to colour fundus photography. However, an adequate grading instrument for Early\u2010AMD lesions within OCT data is missing in the literature as yet. The present paper aims to fill this gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>\u2018EarlyAMDRate\u2019, an instrument for OCT\u2010based grading of Early\u2010AMD lesions, is presented and documented. It comprises a questionnaire assessing a given lesion with respect to its relative position and interaction with the surrounding retinal layers, its brightness, special properties and state of progression (if applicable). Furthermore, the grading procedure includes a graphical masking of the lesion within the OCT image.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For a consecutive sample of <jats:italic>N<\/jats:italic>\u2009=\u2009100 Early\u2010AMD patients, the \u2018EarlyAMDRate\u2019 grading instrument has been applied to leading OCT scans. Examples of masked lesions and processed grading questionnaires are provided. Both raw lesion diameters and cutting sizes follow a log\u2010normal sample distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u2018EarlyAMDRate\u2019 allows for unprecedented detail of description for single Early\u2010AMD lesions which is adequate to the precision of underlying OCT imaging. The obtained grading information allows for a tracking of single lesions and their properties over time as well as for the generation of well\u2010differentiated metric phenotypes for description of Early\u2010AMD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17479","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T19:22:01Z","timestamp":1743448921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u2018EarlyAMDRate\u2019: A grading instrument for OCT\u2010based assessment of early lesions caused by age\u2010related macular degeneration"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9063-1452","authenticated-orcid":false,"given":"Marcus","family":"Wagner","sequence":"first","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5145-7798","authenticated-orcid":false,"given":"Thomas","family":"Peschel","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig University  Leipzig Germany"},{"name":"Department of Ophthalmology Martin Luther University Halle\u2010Wittenberg  Halle Germany"},{"name":"Department of Medical Data Science, Medical Informatics Center Leipzig University Medical Center  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J.","family":"Leutloff","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig University  Leipzig Germany"},{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"},{"name":"Neuroscience Clinical Research Center, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Berliner Hochschule f\u00fcr Technik (BHT)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-0340","authenticated-orcid":false,"given":"Franziska G.","family":"Rauscher","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Leipzig University  Leipzig Germany"},{"name":"Leipzig Research Centre for Civilization Diseases (LIFE) Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(05)80092-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25332"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5576"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12227"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.11.1484"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx228"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac114"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.036"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6987"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.6.643"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13883"},{"key":"e_1_2_11_13_1","unstructured":"Heidelberg Engineering GmbH. 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