{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:10:27Z","timestamp":1784607027527,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","award":["2019\u20104"],"award-info":[{"award-number":["2019\u20104"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271086"],"award-info":[{"award-number":["82271086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore associations between stages of myopic macular degeneration (MMD) and visual acuity and influencing parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants of the population\u2010based study Beijing Eye Study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093468 participants) underwent a detailed ocular and systemic examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Assessable images were available for 3040 (87.7%) individuals (age: 64.0\u2009\u00b1\u20099.7\u2009years). In multivariable analysis, worse best\u2010corrected visual acuity (BCVA) (i.e. higher logMAR values) was associated with higher MMD stage (beta: 0.11;\n                      <jats:italic>B<\/jats:italic>\n                      : 0.06; 95% CI: 0.04, 0.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and thinner subfoveal choroidal thickness (beta: \u22120.06;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), with adjustments for age, sex, educational level, cognitive function, degree of any cataract and prevalence of glaucoma, diabetic retinopathy and age\u2010related macular degeneration. If only eyes with MMD grade 1 or no MMD were included, worse BCVA was associated (multivariable analysis) with higher prevalence of MMD stage 1 (beta: 0.11;\n                      <jats:italic>B<\/jats:italic>\n                      : 0.07; 95% CI: 0.05, 0.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and thinner medium\u2010sized choroidal vessel layer thickness. Correspondingly, BCVA was worse in eyes with MMD stage 1 than in eyes without MMD (0.13\u2009\u00b1\u20090.27 logMAR vs. 0.04\u2009\u00b1\u20090.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Including only eyes without vision\u2010influencing disorders (except myopia), BCVA was also worse in eyes with MMD stage 1 than in eyes without MMD (0.06\u2009\u00b1\u20090.13 logMAR vs. \u22120.01\u2009\u00b1\u20090.08 logMAR;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In these eyes without vision\u2010influencing ocular disorders, worse BCVA was associated with thinner total subfoveal choroidal thickness (beta: \u22120.15;\n                      <jats:italic>R<\/jats:italic>\n                      : 0.000; 95% CI: 0.000, 0.000;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and longer axial length (beta: 0.14;\n                      <jats:italic>R<\/jats:italic>\n                      : 0.01; 95% CI: 0.01, 0.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), or alternatively with higher MMD staging (beta: 0.24;\n                      <jats:italic>R<\/jats:italic>\n                      : 0.09; 95% CI: 0.01, 0.11;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MMD stage 1 (fundus tessellation) is associated with decreased BCVA and may be considered pathological. Independently of longer axial length, thinner choroidal thickness is a factor associated with lower BCVA in myopic eyes, including eyes with MMD stage 1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17480","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:51:57Z","timestamp":1741740717000},"page":"1010-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of fundus tessellation, myopic diffuse chorioretinal atrophy and choroidal thickness with visual acuity in myopia"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Rothschild Foundation Hospital Institut Fran\u00e7ais de Myopie  Paris France"},{"name":"Singapore Eye Research Institute Singapore National Eye Center  Singapore Singapore"},{"name":"Privatpraxis Prof Jonas Und Dr. Panda\u2010Jonas  Heidelberg Germany"},{"name":"New York Eye and Ear Infirmary of Mount Sinai Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Ophthalmology, Medical Faculty Heidelberg Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Privatpraxis Prof Jonas Und Dr. Panda\u2010Jonas  Heidelberg Germany"},{"name":"Department of Ophthalmology, Medical Faculty Heidelberg Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Hospital Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0989","authenticated-orcid":false,"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Hospital Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7793","authenticated-orcid":false,"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Eye Center of Beijing Tsinghua Changgung Hospital Tsinghua Medicine, Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.12.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.07.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.238"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.05.011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316866"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.11.034"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318242b990"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2015.12.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.10.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.040"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10351"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.010"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2023.100350"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.13.11.9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.048"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.01.035"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.031"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.01.035"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.17480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.17480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.17480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:52:23Z","timestamp":1772985143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.17480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/aos.17480"],"URL":"https:\/\/doi.org\/10.1111\/aos.17480","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]},"assertion":[{"value":"2024-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}