{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:10:30Z","timestamp":1784607030582,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271086"],"award-info":[{"award-number":["82271086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To explore the prevalence and associated factors of macular ridges in a population\u2010based study sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      From the participants of the population\u2010based Beijing Eye Study (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093468), we included all eyes with an axial length of \u226525\u2009mm and a randomized sample of the remaining myopic eyes. Using optical coherence tomographic images, we assessed the prevalence and height of macular ridges, defined as an elevation of the foveal region in one meridian.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 366 study eyes, 50 (13.7%; 95% CI: 10.1, 17.2) showed macular ridges. Macular ridge prevalence increased from 0\/78 (0%) in the group with an axial length of \u226423\u2009mm to 18\/71 (25.4%), 7\/27 (25.9%) and 15\/29 (51.7%) in axial length groups of 26\u201326.99\u2009mm, 27\u201327.99\u2009mm and \u226528\u2009mm, respectively. Higher macular ridge prevalence was associated (multivariable analysis) with longer axial length (OR: 1.79; 95% CI: 1.48, 2.16;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and older age (OR: 1.08; 95% CI: 1.04, 1.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Macular ridge height (mean:128\u2009\u00b1\u200979\u2009\u03bcm) increased with longer axial length (0.31; B: 7.84; 95% CI: 5.39, 10.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and older age (beta: 0.16; B: 0.88; 95% CI: 0.34, 1.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Macular ridge orientation was most often in the horizontal meridian (28\/50 eyes; 56%), followed by the vertical meridian (9\/50 eyes; 18%) and the 7 o'clock\u2010to\u20101 o'clock meridian (8\/50 eyes; 16%). It was not significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17) associated with the axis of cylindrical corneal refractive error.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Macular ridges were relatively common in myopic eyes, with macular ridge prevalence and height increasing with longer axial length and older age in a curvilinear manner. They were not significantly associated with corneal astigmatism or best\u2010corrected visual acuity. They may be explained by an inter\u2010plane asymmetry in axial elongation\u2010associated enlargement of Bruch's membrane in the fundus midperiphery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17494","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:50:16Z","timestamp":1744347016000},"page":"1058-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Macular ridges: Prevalence and associated factors\u2014The Beijing Eye Study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Rothschild Foundation Hospital Institut Fran\u00e7ais de Myopie  Paris France"},{"name":"Singapore Eye Research Institute Singapore National Eye Center  Singapore City Singapore"},{"name":"Privatpraxis  Heidelberg Germany"},{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine Tsinghua University  Beijing China"},{"name":"L V Prasad Eye Institute  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Privatpraxis  Heidelberg Germany"},{"name":"Department of Ophthalmology, Medical Faculty Heidelberg Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-0989","authenticated-orcid":false,"given":"Wen Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7793","authenticated-orcid":false,"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine Tsinghua University  Beijing China"},{"name":"Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital Capital Medical University  Beijing 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