{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:12:45Z","timestamp":1791601965334,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007707","name":"University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007707","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To provide a perspective on the feasibility and utility of automating image segmentation with artificial intelligence (AI)\u2013based deep\u2010learning algorithms to quantify retinoschisis cystic cavity volume in patients with X\u2010linked retinoschisis (XLRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Review outcomes of two studies published in this journal issue of Acta Ophthalmological on implementing AI\u2013based analysis of Optical Coherence Tomography (OCT) retinal images to quantify structural cavities in XLRS patients. Analyse results of using AI\u2010analytics compared with human manual segmentation for grading the same set of retinal OCT images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both papers were successful in developing independent, AI\u2013based algorithms to automate and quantify the extent of schisis cavity spaces in the retina of XLRS patients. Both studies demonstrated that AI analytics can give results comparable to or better than human performance for quantifying XLRS structural dysmorphology. One group then simulated a clinical therapy trial comparing CAI treatment against controls; changes in AI\u2010quantified schisis volume (ASV) proved a better metric as a trial structural endpoint than either central subfield thickness (CST) or central foveal thickness (CFT) as trial structural endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These two studies independently demonstrated the feasibility of automating the laborious process of quantifying retinoschisis cavity volume in XLRS patients. Further, automated AI\u2010based cavity volume measurement was demonstrated to be feasible as a possible outcome for XLRS therapeutic trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17499","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T21:48:29Z","timestamp":1745617709000},"page":"725-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>AI<\/scp> image analysis tools quantify schisis cystic volume in <scp>XLRS<\/scp> retinal dysmorphology"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-577X","authenticated-orcid":false,"given":"Paul A.","family":"Sieving","sequence":"first","affiliation":[{"name":"Center for Ocular Regenerative Therapy UC Davis School of Medicine  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000237081.80600.51"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.05.025"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902920402"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8600"},{"key":"e_1_2_4_6_1","volume-title":"Analysis of the slow transretinal potentials in response to light","author":"Faber D.S.","year":"1969"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1204095"},{"key":"e_1_2_4_8_1","first-page":"343","article-title":"Uber das Zusammenvorkommen von Veraenderungen der Retina und Choroidea","volume":"37","author":"Haas J.","year":"1989","journal-title":"Archiv f\u00fcr Augenheilkunde"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17495"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.12.003"},{"key":"e_1_2_4_11_1","first-page":"816","article-title":"Expression of X\u2010linked retinoschisis protein RS1 in photoreceptor and bipolar cells","volume":"42","author":"Molday L.L.","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI81380"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2022.06.013"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00578-2"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1097-164"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15121583"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17485"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/385313a0"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.6.2117"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.17499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T05:04:03Z","timestamp":1754975043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.17499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/aos.17499"],"URL":"https:\/\/doi.org\/10.1111\/aos.17499","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}