{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:15:22Z","timestamp":1791602122634,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the effectiveness of laser prophylaxis in preventing retinal detachment (RD) in patients with Stickler syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed to identify studies that compared RD rates between eyes that received laser prophylaxis and eyes that received no laser prophylaxis in patients with Stickler syndrome. Data sets from the included studies were pooled and analysed. Individual eyes that presented with RD and eyes without RD with &lt;6\u2009months of follow\u2010up were excluded. The primary outcome was the rate of RD. The study was conducted in accordance with the PRISMA guideline 2020 for systematic reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 6 articles included in the meta\u2010analysis, including 400 eyes of 225 patients. RD rate was 6.6% (19 of 289) in eyes with laser compared to 36.0% (40 of 111) in eyes with no laser (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001, chi\u2010square) with a mean follow\u2010up interval of 6.3\u2009years for eyes with laser and 4.0\u2009years for eyes with no laser. The pooled risk ratio for retinal detachment after laser prophylaxis was 0.23 (95% CI: 0.13\u20130.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prophylactic laser therapy was associated with a significantly lower risk of RD in patients with Stickler syndrome compared to no laser prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17509","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T03:55:22Z","timestamp":1747281322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laser prophylaxis for retinal detachment in Stickler syndrome: A\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-1189","authenticated-orcid":false,"given":"David A.","family":"Camp","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaquib R.","family":"Bakhsh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Torkashvand","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan R.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Dean McGee Eye Institute University of Oklahoma  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameay V.","family":"Naravane","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Neurosciences University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Belin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Neurosciences University of Minnesota  Minneapolis Minnesota USA"},{"name":"Retinal Consultants of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly A.","family":"Quiram","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Neurosciences University of Minnesota  Minneapolis Minnesota USA"},{"name":"Retinal Consultants of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsveta","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Manchester Royal Eye Hospital NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Wubben","sequence":"additional","affiliation":[{"name":"Department of 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