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Additionally, 83 healthy volunteers were scanned using 3D whole\u2010brain magnetic resonance encephalography (MREG). Ocular pulsation power across very low\u2010frequency, respiratory and cardiac bands was quantified in each individual.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical tropicamide significantly reduced physiological pulsation power throughout the eye, including the cornea, lens, vitreous body, retina and optic nerve. Similar reductions were observed in the untreated eye, indicating potential systemic effects. In the brain, significant pulsation changes were noted in the venous sinus and internal carotid artery following tropicamide application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings suggest parasympathetic activity is crucial in modulating physiological pulsations in both ocular and cerebral glymphatic pathways. This interplay may have implications for conditions involving impaired fluid dynamics, such as glaucoma and traumatic brain injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17510","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T04:50:02Z","timestamp":1746679802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-7017","authenticated-orcid":false,"given":"Seyed Mohsen","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"Oulu Functional Neuroimaging (OFNI), Department of Diagnostic Imaging Oulu University Hospital  Oulu Finland"},{"name":"Health Science and Technology (HST), Faculty of Medicine University of Oulu  Oulu 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