{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:22:37Z","timestamp":1760746957611,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of the study is to compare the risk of first\u2010line photodynamic therapy (PDT) failure according to the PDT protocol performed in patients with exudative choroidal circumscribed hemangioma (CCH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included patients from 11 European centres in France, Italy and Denmark. Two groups were established: patients treated with Standard Protocol PDT (SP\u2010PDT) and patients treated with a \u2018Fast\u2019 Protocol PDT (FP\u2010PDT), characterised by laser irradiation without delay after the end of the verteporfin infusion (8\u2009min after start of infusion). We analysed groups on the risk of exudative CCH recurrence requiring a second line of treatment, defining the first\u2010line PDT failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 111 patients were included in the study: 76 treated with the SP\u2010PDT and 35 with the FP\u2010PDT. First\u2010line PDT failure was observed for 45 patients (59%) in the SP\u2010PDT group and 9 patients (26%) in the FP\u2010PDT group, with a median follow\u2010up of 3.5 [1.7\u20136.7] years and 2.3 [0.8\u20133.9] years, respectively. Final best\u2010corrected visual acuity (BCVA) improvement did not differ between groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.49). A multivariate survival analysis including initial CCH thickness and initial BCVA was performed over a two\u2010year follow\u2010up period: FP\u2010PDT as first\u2010line treatment was significantly associated with a lower risk of PDT failure [HR\u2009=\u20090.27, 95%CI (0.11\u20130.65)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FP\u2010PDT shows encouraging results in the treatment of CCHs, as it is associated with a lower risk of PDT failure. It may therefore represent an interesting avenue for optimised PDT parameters, although these results need to be confirmed by randomised trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aos.17513","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T05:33:57Z","timestamp":1746423237000},"page":"831-841","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4075-4187","authenticated-orcid":false,"given":"Paul","family":"Dubar","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaud","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Croix\u2010Rousse  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9575-7449","authenticated-orcid":false,"given":"Emilie","family":"Hucteau","sequence":"additional","affiliation":[{"name":"University of Bordeaux, Inserm, BPH, U1219, LEHA Team  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-496X","authenticated-orcid":false,"given":"Juliette","family":"Thariat","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Fran\u00e7ois Baclesse Center\/ARCHADE\u2010Normandie University  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Nhari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Croix\u2010Rousse  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia","family":"Maschi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Pasteur 2  Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-1460","authenticated-orcid":false,"given":"Jens Folke","family":"Kiilgaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Mosci","sequence":"additional","affiliation":[{"name":"Clinica Oculista, E.O. 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