{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:04:45Z","timestamp":1769778285188,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013511","name":"Silm\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013510","name":"Silm\u00e4- ja kudospankkis\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011905","name":"Evald ja Hilda Nissin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015738","name":"Mary och Georg C. Ehrnrooths Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To report long\u2010term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, in part prospective, hospital\u2010based longitudinal follow\u2010up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow\u2010up was 7.3\u2009years (range, 0.3\u201315.2). Symptoms, best corrected visual acuity, pattern in axial power map, astigmatism, corneal thickness, higher order irregularity, cavities, progression and human leukocyte antigen genes were analysed. In 13 blood samples, 483 corneal and inflammatory disease\u2010related genes were analysed with exome sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age at first examination was 61\u2009years (range, 13\u201389). Eleven (69%) patients were male, and 13 (81%) had bilateral disease. The median annual rate of progression of topographic astigmatism and new thinning was 0.03 D (range, \u22121.50 to 3.60) and 12.9\u2009\u03bcm (range, \u2212107.8 to 93.0), respectively; 0.15 D (range \u22121.50 to 1.17) and 21.6\u2009\u03bcm (range, 1.3\u201393.0) in 6 (38%) patients with fast progression, and 0.02 D (range, \u22120.06 to 3.60) and 4.1\u2009\u03bcm (range, \u2212107.8 to 24.7) in 10 (72%) patients with slow progression. Topographic pattern, unilaterality, cavities, sectoral hyperaemia, poor response to medical treatment and new thinning after surgery were associated with fast progression. Thickness at maximal thinning fell below 450\u2009\u03bcm only with fast progression. Five eyes changed the topographic pattern. Coexisting keratitis fugax hereditaria was found in one patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A subtype of TMD progresses faster. The most sensitive indicators of progression were thinning and topographic astigmatism. No shared genetic cause for TMD was identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17524","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T08:34:47Z","timestamp":1747643687000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Progression and topographic subtypes of Terrien marginal degeneration"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0476-5647","authenticated-orcid":false,"given":"Minna","family":"Ruutila","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Repo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Eye Genetics Group Folkh\u00e4lsan Research Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamari T.","family":"Immonen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Eye Genetics Group Folkh\u00e4lsan Research Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joni A.","family":"Turunen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Eye Genetics Group Folkh\u00e4lsan Research Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja\u2010Liisa","family":"Lokki","sequence":"additional","affiliation":[{"name":"Transplantation Laboratory, Department of Pathology University of Helsinki  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Inkeri","family":"Lokki","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology University of Helsinki  Helsinki Finland"},{"name":"Translational Immunology Research Program, Research Programs Unit University of Helsinki  Helsinki Finland"},{"name":"Heart and Lung Center Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Moilanen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Krootila","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tero T.","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.TJO-D-23-00176"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90768-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040010244012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.07.031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_609_21"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.09.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.14.10.510"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2011.05.002"},{"key":"e_1_2_7_11_1","first-page":"432","article-title":"La d\u00e9g\u00e9n\u00e9rescence marginale de la corn\u00e9e","volume":"53","author":"Fran\u00e7ois J.","year":"1936","journal-title":"Archives d'Ophtalmologie (Paris)"},{"key":"e_1_2_7_12_1","unstructured":"Frank K.(1896)Klinische und pathologisch\u2010anatomische beitr\u00e4ge zu den erkrankungen der hornhaut: chronische periphere furchenkeratitis (indolentes randfurchengeschw\u00fcr) ulcus rodens pneumococcenophtalmie und atypischer fr\u00fchjahrskatarrh.Department of Ophtalmology University of Marburg Universit\u00e4ts Buchdruckerei (C.L. 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