{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:48:24Z","timestamp":1792622904948,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We investigated relationships between two dietary composite scores and myopic macular degeneration (MMD) in a high myopia adult cohort, as there is a knowledge gap regarding the role of diet in MMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a cross\u2010sectional analysis of a population\u2010based prospective cohort, the Aier\u2010Singapore Eye Research Institute (SERI) high myopia cohort study of Chinese adults, in Changsha, central China. Systemic and ocular (including cycloplegic spherical equivalent [SE] and axial length [AL]) assessments were carried out. A self\u2010administered food frequency questionnaire was used to assess the dietary intake. Dietary intake was categorised into 13 food groups (refined grains, whole grains, meat, fish, processed\/unhealthy meat, plant\u2010based protein, fruits, vegetables, fast food and savoury snacks, dairy products, desserts and sweet snacks, sugar\u2010sweetened beverages, and alcohol). Using exploratory factor analysis, two dietary patterns (Dietary Pattern 1 [less healthy] and 2 [healthier]) were identified. Multivariable logistic regression analyses with Bonferroni corrections were performed to assess associations between diet and MMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 445 participants, 71 (16.0%) had MMD. The participants had an overall mean age of 42.3\u2009\u00b1\u20097.3\u2009years, SE of \u22129.5\u2009\u00b1\u20094.3 dioptres (D) and AL of 27.3\u2009\u00b1\u200911.86\u2009mm. In the multivariable analyses, none of the 13 food groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.004 for all) or 2 dietary patterns (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for both) were associated with MMD, after adjusting for age, sex, education, SE and AL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We did not find associations between diet and MMD in a cohort of highly myopic adults. There is currently no dietary advice to prevent MMD. Larger and prospective studies conducted over multiple time points are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17528","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:01:31Z","timestamp":1747638091000},"page":"891-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diet and myopic macular degeneration in the Aier\u2010\n                    <scp>SERI<\/scp>\n                    high myopia adult cohort study"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-1107","authenticated-orcid":false,"given":"Kai\u2010Xiong","family":"Cheong","sequence":"first","affiliation":[{"name":"Singapore National Eye Centre Singapore Eye Research Institute  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meible","family":"Chi","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"Aier Academy of Ophthalmology Central South University  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qi","family":"Lee","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Programme in Health Services and Systems Research Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Hu","sequence":"additional","affiliation":[{"name":"Changsha Aier Eye Hospital  Changsha People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hla Myint","family":"Htoon","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre Singapore Eye Research Institute  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan V.","family":"Hoang","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre Singapore Eye Research Institute  Singapore Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"},{"name":"Ophthalmology &amp; Visual Sciences Academic Clinical Program (Eye ACP), Duke\u2010NUS Medical School  Singapore Singapore"},{"name":"Department of Ophthalmology, Edward S. Harkness Eye Institute Columbia University Vagelos College of Physicians and Surgeons  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Foong\u2010Fong","family":"Chong","sequence":"additional","affiliation":[{"name":"Saw Swee Hock School of Public Health National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Lan","sequence":"additional","affiliation":[{"name":"Aier Academy of Ophthalmology Central South University  Changsha Hunan People's Republic of China"},{"name":"Changsha Aier Eye Hospital  Changsha People's Republic of China"},{"name":"Aier School of Optometry and Vision Science Hubei University of Science and Technology  Xianning Hubei People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seang\u2010Mei","family":"Saw","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre Singapore Eye 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