{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:43:42Z","timestamp":1787773422716,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate changes in choroidal thickness (CT), choroidal blood flow and axial length (AL) after therapy with either 0.01% atropine eye drops (AT) or the combination of orthokeratology and 0.01% AT (OKA) among Japanese myopic children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed changes in CT, choroidal blood flow and AL among myopic children who received either 0.01% AT or the OKA therapy at Toho University Omori Hospital from January 2021 through December 2022 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200938 eyes, 8.26\u2009\u00b1\u20092.13\u2009years old in the 0.01% AT group and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944 eyes, 8.36\u2009\u00b1\u20091.54\u2009years old in the OKA group). Comprehensive ophthalmologic examinations were performed at baseline, 3, 6 and 12\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subfoveal CT increased in the OKA group more than that in the AT group at 3, 6 and 12\u2009months. Choroidal blood flow increase was greater in the OKA group compared to that in the AT group at 6 and 12\u2009months. AL increase was less in the OKA group than that in the AT group at 6 and 12\u2009months. AL changes were negatively correlated with choroidal blood flow and CT changes at both time points. In multivariate analysis, age, male, CT change and choroidal blood flow were independently associated with AL changes at 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The increase in CT was more pronounced in the combination therapy group compared to the AT group. The increase in CT and choroidal blood flow was associated with a reduced AL progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17537","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T04:35:33Z","timestamp":1752726933000},"page":"974-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in choroidal thickness and blood flow in myopic children with 0.01% atropine or orthokeratology and atropine combination therapy"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6157-9058","authenticated-orcid":false,"given":"Saiko","family":"Matsumura","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Itokawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Toho University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Orthoptics and Visual Science, School of Allied Health Sciences Kitasato University  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Toho University Faculty of Medicine  Tokyo 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