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The participants were assigned to either SMPL treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009103) or sham therapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200956). Ophthalmic evaluations were performed at baseline (T1), 3\u2009months (T2) and 12\u2009months (T3) to assess BCVA and optical coherent tomography (OCT) parameters, including CRT, macular thickness (MT), macular volume (MV), and hyperreflective spots (HRS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the SMPL group, BCVA improved after 3\u2009months (T2\u2009&gt;\u2009T1;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002); MT decreased after 12\u2009months (T2, T1\u2009&gt;\u2009T3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); MV decreased after 12\u2009months (T2, T1\u2009&gt;\u2009T3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001); HRS count decreased after 3 and 12\u2009months (T1\u2009&gt;\u2009T2, T3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The decrease in CRT after 3\u2009months was greater in the SMPL group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The need for rescue therapy was lower in the SMPL group (9.7% vs. 19.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). BCVA, CRT, MV, MT and HRS remained stable in the sham group, while microaneurysms count was stable in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SMPL is safe and effective for the prophylaxis of mild DME, as it reduces MT and MV while keeping BCVA stable. The decreased need for rescue anti\u2010vascular endothelial growth factor therapy suggests that it may delay or reduce intravitreal injections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17548","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T02:23:48Z","timestamp":1751077428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response to subthreshold micropulse laser treatment in the prophylaxis of diabetic macular oedema: A preliminary study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-0572","authenticated-orcid":false,"given":"Barbara","family":"Sabal","sequence":"first","affiliation":[{"name":"Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze Medical University of Silesia  Katowice Poland"},{"name":"Department of Ophthalmology John Paul II Municipal Hospital  Rzeszow 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