{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:14:06Z","timestamp":1769775246882,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the prognosis and determinants of survival after orbital exenteration in patients with conjunctival melanoma (CoM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective study, 27 consecutive patients who underwent exenteration for CoM from 2001 to 2023 were included. Overall survival (OS), progression\u2010free survival (PFS) and their risk factors were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean follow\u2010up time since orbital exenteration was 42\u2009\u00b1\u200937\u2009months. Eyelid sparing orbital exenteration was achieved in 24 patients (89%). Two patients (7%) developed local recurrences. Seven patients (26%) developed distant metastasis resulting in a metastasis\u2010free survival of 100% at 1\u2009year and 63% at 5\u2009years. The PFS was 100% and 63% at 1 and 5\u2009years, respectively. The OS for 1, 5 and 10\u2009years was 92, 57 and 31%, respectively. Presence of recurrences prior to exenteration and longer time from diagnosis to exenteration were related to worse OS (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Presence of metastasis prior to exenteration, orbital invasion and tumour\u2010containing resection margins were related to a worse PFS at 5\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For CoM patients treated with orbital exenteration, the presence of metastases and recurrences prior to exenteration, longer time from diagnosis to exenteration, orbital invasion and tumour\u2010containing resection margins are unfavourable prognostic factors. Our study demonstrates relatively favourable outcomes, with no difference in survival between eyelid sparing or eyelid removing techniques, calling to consider orbital exenteration for advanced CoM cases when other (newer) therapies are not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17553","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T06:13:56Z","timestamp":1752300836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis and determinants of survival after orbital exenteration for conjunctival melanoma: Experiences from a Dutch Referral Centre"],"prefix":"10.1111","volume":"104","author":[{"given":"David","family":"Chetroiu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-0859","authenticated-orcid":false,"given":"Niels J.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Marinkovic","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorius P. 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Khanh","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-560X","authenticated-orcid":false,"given":"Stijn W.","family":"van der Meeren","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The 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