{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:43:18Z","timestamp":1790790198147,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the role of spectral domain optical coherence tomography (SD\u2010OCT)\u2010based biomarkers in predicting treatment response of macular oedema (MO) secondary to retinal vein occlusion (RVO) to anti\u2010vascular endothelial growth factor (VEGF) therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study including consecutive cases of RVO associated MO who received anti\u2010VEGF injections between January 2020 and April 2021. LogMAR visual acuity (VA) at baseline, 12 and 24\u2009months was correlated with a panel of SD\u2010OCT\u2010based biomarkers, including vitreomacular status, size of intra\u2010retinal cysts (IRC), presence of disorganization of retinal inner layers (DRIL), hyper\u2010reflective foci (HRF) in the retina, integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), cone outer segment tip (COST) and presence of subretinal fluid (SRF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and thirty eyes were included with 81 and 49 eyes in the BRVO and CRVO subgroup, respectively. In both subgroups, baseline disrupted EZ\/ELM [BRVO: (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.144\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.111\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.096\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042) and CRVO: (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.316\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.336\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.327\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001)] were associated with worse VA from baseline through 24\u2009months. In the BRVO subgroup, the presence of HRF (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.209\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) correlated with worse baseline VA. Improvement in DRIL extent [OR\u2009=\u20094.355 (1.109\u201317.094)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035; OR\u2009=\u20094.510 (1.707\u201311.917)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002] and EZ\/ELM integrity [OR\u2009=\u20094.474 (1.783\u201311.223)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; OR\u2009=\u20093.214 (1.414\u20137.305)\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005] were associated with a higher likelihood of achieving at least a 5 letters gain at 12 and 24\u2009months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A comprehensive system of SD\u2010OCT\u2010based features could predict functional outcomes of MO secondary to RVO with anti\u2010VEGF therapy up to 24\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.17574","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T13:04:47Z","timestamp":1754312687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["SD\u2010OCT\u2010based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti\u2010VEGF therapy"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-694X","authenticated-orcid":false,"given":"Ken K.","family":"Tsang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Hong Kong Eye Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian W. K.","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Hong Kong Eye Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M. K.","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Hong Kong Eye Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4728-0076","authenticated-orcid":false,"given":"Ziqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-9060","authenticated-orcid":false,"given":"Dawei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-6593","authenticated-orcid":false,"given":"Truong X.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheeda","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong Special Administrative Region China"},{"name":"Hong Kong Eye Hospital  Hong Kong Special Administrative Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-6428","authenticated-orcid":false,"given":"Timothy Y. 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