{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:28Z","timestamp":1787013868492,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:00:00Z","timestamp":1758412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273648"],"award-info":[{"award-number":["82273648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574119"],"award-info":[{"award-number":["82574119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8227120378"],"award-info":[{"award-number":["8227120378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Myopia is a growing concern in children worldwide, leading to significant visual impairments. This study investigates the efficacy of plano spectacle lenses with lenslets in preventing the onset of myopia in pre\u2010myopic children. This study aims to contribute to the development of evidence\u2010based strategies for myopia prevention by assessing compliance, efficacy and safety of plano spectacle lenses with lenslets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial involves 388 pre\u2010myopic children aged 6\u20139\u2009years. Participants are randomly assigned to either the intervention group, using plano spectacle lenses with lenslets for at least 8\u2009h daily with smart frames recording wearing time, or the control group, which receives no intervention. The primary outcome is the 1\u2010year cumulative incidence of myopia. Secondary outcomes include changes in spherical equivalent under cycloplegia, axial length, choroidal thickness, visual acuity and accommodation function over the study period. Statistical analyses, including chi\u2010squared tests and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, will evaluate these outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study will offer valuable insights into the use of plano spectacle lenses with lenslets in slowing down the progression to myopia in children at risk. Findings are expected to inform clinical practices and shape guidelines for myopia prevention strategies among the paediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>NCT06860737.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70007","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:44:37Z","timestamp":1758516277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A randomized clinical trial on the effectiveness of plano spectacle lenses with lenslets on myopia prevention in pre\u2010myopic children: Study protocol of a randomized controlled trial"],"prefix":"10.1111","volume":"104","author":[{"given":"Jingjing","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; Treatment Center\/Shanghai Eye Hospital, School of Medicine \u4e28 National Clinical Research Center for Eye Diseases \u4e28 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Du","sequence":"additional","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; Treatment Center\/Shanghai Eye Hospital, School of Medicine \u4e28 National Clinical Research Center for Eye Diseases \u4e28 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; Treatment Center\/Shanghai Eye Hospital, School of Medicine \u4e28 National Clinical Research Center for Eye Diseases \u4e28 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; Treatment Center\/Shanghai Eye Hospital, School of Medicine \u4e28 National Clinical Research Center for Eye Diseases \u4e28 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliuxing","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Eye Diseases Prevention &amp; 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