{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:53:24Z","timestamp":1775638404374,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016063","name":"Stichting Steunfonds Uitzicht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010374","name":"Stichting Blindenhulp","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study evaluates whether mesopic microperimetry (MMP) provides a more robust measure of retinal function compared to visual acuity (VA) in age\u2010related macular degeneration (AMD) clinical trials, with a focus on optimal analysis strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Fellow\u2010eyes of unilateral neovascular AMD were prospectively studied. Presenting VA was measured. The Macular Integrity Assessment Microperimeter (MAIA) was used with a 4 to 2 staircase strategy with a 10\u00b0 diameter grid containing 37 loci. Three analysis strategies were calculated: the mean of 37 sensitivity thresholds (MS), the per cent reduced threshold (PRT), and the log\u2010transformed candela mean (MS cd log). Sample size requirements were calculated for 12\u2010 and 24\u2010month follow\u2010ups using a paired one\u2010sided T\u2010test (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05, power\u2009=\u20090.80).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009123 were analysed (82 (65.5%) females; mean age 74.2 (7.8) years). Ranked high to low, the required sample size at 12\u2009months was: MS (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951), MS cd log (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952), PRT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009139), and VA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009203). Similar trends were seen at 24\u2009months, with MS requiring the smallest sample size (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200985) and VA the largest (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091673).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>All MMP analysis strategies outperformed VA, and MS required the least number of patients to show significant changes. This trend was consistent for both 12 and 24\u2009months. These findings provide strong statistical arguments for the use of MMP in longitudinal within\u2010subjects clinical trials and suggest that averaging decibels is optimal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70008","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T08:09:24Z","timestamp":1758528564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Power and clinical utility of mesopic microperimetry analysis strategies in age\u2010related macular degeneration"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-6241","authenticated-orcid":false,"given":"Francesco","family":"Cinque","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-6690","authenticated-orcid":false,"given":"Jeroen","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahfam","family":"Shahabi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Sluijterman","sequence":"additional","affiliation":[{"name":"Section Biostatistics, IQ Health Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofie","family":"ten Brink","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"de Breuk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Heesterbeek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-5258","authenticated-orcid":false,"given":"Caroline","family":"Klaver","sequence":"additional","affiliation":[{"name":"Department 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