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We included patients of 55\u2009years or older with nAMD in one or both eyes, without the presence of drusen or signs of another underlying disease in either eye. The medical charts and multimodal imaging (MMI) were evaluated by two independent graders. Eyes were divided into two groups: polypoidal choroidal vasculopathy (PCV)\u2010associated macular neovascularization (MNV) and non\u2010PCV MNV. We evaluated the visual acuity (VA) at baseline and 1\u2009year after baseline; complete resolution of macular fluid on optical coherence tomography (OCT) during 1\u2009year of follow\u2010up; required treatments to achieve a complete resolution of macular fluid on OCT; complication rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 106 eyes of 99 patients, with a median age of 73\u2009years. Seventy\u2010one eyes had PCV\u2010associated MNV, and 35 eyes had non\u2010PCV MNV. The overall median baseline VA was 0.22 logMAR (Snellen 20\/30), and 0.15 logMAR (Snellen 20\/28) at 1\u2009year follow\u2010up. Subretinal haemorrhage was more common in PCV\u2010associated MNV compared to non\u2010PCV MNV, both at initial presentation (21% vs. 17%) and during the 1 year follow\u2010up period (23% vs. 11%). In total, 31 out of 48 eyes (65%) achieved complete resolution of macular fluid on OCT during follow\u2010up, most commonly achieved with combined photodynamic therapy (PDT)\u2009+\u2009intravitreal anti\u2010vascular endothelial growth factor (anti\u2010VEGF) injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>nAMD can occur without the presence of drusen in either eye. Treatment with anti\u2010VEGF injections, PDT or a combination thereof appears to be effective, but more research is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70010","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:42:12Z","timestamp":1760557332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neovascular age\u2010related macular degeneration without drusen"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8788-7753","authenticated-orcid":false,"given":"Marc J.","family":"Sirks","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Amsterdam University Medical Center  Amsterdam The Netherlands"},{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The\u00a0Netherlands"},{"name":"Rotterdam Eye Hospital  Rotterdam The\u00a0Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elon H. 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