{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:54:34Z","timestamp":1775638474775,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pregnancy induces significant changes in the body, including increased peripheral and choroidal blood perfusion and an increased systemic corticosteroid level. Here, we systematically reviewed the evidence on pregnancy as a risk factor for developing central serous chorioretinopathy (CSC) and conducted a meta\u2010analysis to obtain a summary estimate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched 12 literature databases on 16 February 2025 for epidemiological studies, which evaluated the potential association between pregnancy and CSC. All eligible studies were included for a qualitative review and a meta\u2010analysis. The meta\u2010analysis was made using the random\u2010effects model on the odds ratio (OR) of the association between pregnancy and CSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four studies were eligible for our review. Of the 2766 individuals (1345 patients with CSC, 1391 controls) in these studies, females constituted 26%\u201364% of study populations in individual studies. The calculated summary estimate of pregnancy as a risk factor for CSC was OR 5.51 (95% CI: 2.12\u201314.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00046). Heterogeneity statistics suggested minimal to no heterogeneity (Cochran's\n                      <jats:italic>Q<\/jats:italic>\n                      \u2009=\u20090.72;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%), the funnel plot was symmetrical and the sensitivity analysis suggested robustness of the estimates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pregnancy appears to be a significant risk factor for CSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70013","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T04:10:06Z","timestamp":1759291806000},"page":"259-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy as a risk factor for central serous chorioretinopathy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"104","author":[{"given":"Nathalie Skovgaard","family":"Eriksen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Fakhril\u2010din","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2670-483X","authenticated-orcid":false,"given":"Riccardo","family":"Fasana","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Anguita","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"Department of Ophthalmology, Inselspital, University Hospital Bern University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elon H. C.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Rotterdam Eye Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-6369","authenticated-orcid":false,"given":"Lorenzo","family":"Ferro Desideri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Inselspital, University Hospital Bern University of Bern  Bern Switzerland"},{"name":"Department for Bio Medical Research University of Bern  Bern Switzerland"},{"name":"Bern Photographic Reading Center, Inselspital University Hospital Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Grauslund","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Ophthalmology Vestfold Hospital Trust  T\u00f8nsberg Norway"},{"name":"Department of Region Health Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-7455","authenticated-orcid":false,"given":"Michael","family":"Stormly Hansen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver Niels","family":"Klefter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Motaabbed","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Hanusch Hospital  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-2650","authenticated-orcid":false,"given":"Line","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prithvi","family":"Ramtohul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Nord Aix\u2010Marseille University  Marseille France"},{"name":"Vitreous Retina Macula Consultants of New York  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Cem","family":"Sabaner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Bilecik Training and Research Hospital  Bilecik T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"Savran","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-4743","authenticated-orcid":false,"given":"Miklos","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Ophthalmology Semmelweis University  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousif","family":"Subhi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"},{"name":"Department of Region Health Research University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.137169"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000586"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061706"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15112"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526052"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2016.1276196"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0158-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312431"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2024.101236"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17520"},{"key":"e_1_2_7_12_1","article-title":"Predictive factors for morphological and functional improvements in long\u2010lasting central serous chorioretinopathy treated with photodynamic therapy","volume":"13","author":"Gaw\u0119cki M.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.024"},{"key":"e_1_2_7_14_1","unstructured":"Higgins J.P.T. Thomas J. Chandler J. Cumpston M. Li T. Page M.J.et\u00a0al. (Eds.). (2024)Cochrane handbook for systematic reviews of interventions version 6.5(updated August 2024). Cochrane. Available from:www.training.cochrane.org\/handbook[Accessed 16th February 2025]."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154437"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.18502\/jovr.v18i4.14553"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.02.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17459"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2012.02848.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0169-x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1290.016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000080"},{"key":"e_1_2_7_24_1","first-page":"439","article-title":"Central serous choroidopathy in pregnancy","volume":"53","author":"Normalina M.","year":"1998","journal-title":"The Medical Journal of Malaysia"},{"key":"e_1_2_7_25_1","first-page":"382","article-title":"Central serous chorioretinopathy in pregnancy","volume":"66","author":"Ochinciuc R.","year":"2022","journal-title":"Romanian Journal of Ophthalmology"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0300-1652.170380"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16679"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2015.0056"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30730-6"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02812-5"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.97920"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2005.10.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0937-5"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30386-2"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.100973"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2020.100856"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13091548"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066858"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15115"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000790"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13952"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14777-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5580075"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12141"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:07:34Z","timestamp":1775635654000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/aos.70013"],"URL":"https:\/\/doi.org\/10.1111\/aos.70013","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,30]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}