{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:30Z","timestamp":1787013870501,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the incidence, outcomes, and risk factors of numerical hypotony (NH) and choroidal effusion (CE) following standalone PRESERFLO MicroShunt (PMS) implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary open\u2010angle glaucoma (POAG) and pseudoexfoliative glaucoma (PXG) patients with uni\u2010 or bilateral surgery at a tertiary university hospital were retrospectively evaluated. Kaplan\u2013Meier estimates of first\u2010operated eyes were used to analyse the cumulative incidence of NH (intraocular pressure [IOP] of &lt;6\u2009mmHg), CE, and CE requiring intervention. Risk factor analyses were performed using generalised linear mixed models on the patient level, including bilateral cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 370 patients (235 POAG and 135 PXG) and 435 eyes (288 and 147) were included. The PXG group had a significantly higher incidence of NH (83.7% vs. 69.4%) and CE (34.6% vs. 20.6%). Interventions for CE were required significantly more in PXG patients (20.7% vs. 7.4%). The median CE duration was significantly longer in the PXG group (14\u2009days vs. 7\u2009days). The following risk factors were identified: PXG (development of NH, CE, and CE requiring intervention); spherical hyperopic refractive error (CE and CE requiring intervention); male sex and higher age (CE); number of preoperative medications (CE requiring intervention), lower preoperative IOP (NH), and higher postoperative IOP drop (CE). The 6\u2010month visual outcomes were not influenced by the hypotony criteria, but significantly more eyes treated for CE required subsequent bleb revisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PXG and hyperopic eyes were at risk for developing postoperative CE requiring intervention. They should be monitored more closely and would benefit from primary intraluminal stenting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70018","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:19:47Z","timestamp":1761070787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence, risk factors, and outcomes of numerical hypotony and choroidal effusion following\n                    <scp>PRESERFLO MicroShunt<\/scp>\n                    implantation"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3375-702X","authenticated-orcid":false,"given":"Emil","family":"Nasyrov","sequence":"first","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Kommerell","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabell","family":"Schleicher","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4485-5580","authenticated-orcid":false,"given":"David A.","family":"Merle","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-126X","authenticated-orcid":false,"given":"Bogomil","family":"Voykov","sequence":"additional","affiliation":[{"name":"Centre for Ophthalmology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-5-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33482-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15727"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-008-9193-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-022-02342-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00227-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1060-y"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05831-2"},{"key":"e_1_2_7_11_1","first-page":"343","volume-title":"Contemporary ophthalmology honoring sir Stewart Duke\u2010Elder","author":"Gass J.","year":"1972"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71860-4"},{"key":"e_1_2_7_13_1","first-page":"1417","article-title":"Risk factors for choroidal detachment after trabeculectomy with mitomycin C","volume":"7","author":"Haga A.","year":"2013","journal-title":"Clinical Ophthalmology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.13.26"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-019-01267-6"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77379-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.7.914"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16658"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041677"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.14374"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2024.2436101"},{"key":"e_1_2_7_23_1","first-page":"951","article-title":"Pseudoexfoliation syndrome for the comprehensive ophthalmologist","volume":"105","author":"Naumann G.O.","year":"1998","journal-title":"Intraocular and Systemic Manifestations. 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