{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:32:04Z","timestamp":1788402724849,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>It is important for clinicians to identify patients with glaucoma at higher risk of poor adherence to topical therapy at an early stage to prescribe alternative treatments. An expert\u2010based set of statements was developed to assist clinicians in the early identification of patients at high risk of low adherence and subsequent poorer clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010step strategy was used. First, statements were developed by a panel of experts using data from a literature search as a starting point. Second, we measured agreement with the statements in a representative group of ophthalmologists managing patients affected by glaucoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 18 statements and consensus was reached for all. The available evidence and clinical experience have identified some subpopulations at high risk of poor adherence. These include young individuals with competing interests, being frequently away from home, multiple comorbidities and particularly when they affect joint function of the hands or cognitive abilities, being asymptomatic, and being poorly informed about the severity of the disease. The unavailability of caregivers and living alone seems to be relevant factors, particularly in older and more frail patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together our results allow us to profile patients with glaucoma who will be more likely to show poor adherence to topical treatments. Moreover, the consensus statements can be used to identify patients who are unsuitable for topical drops and who would benefit more from alternative treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70024","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T07:49:32Z","timestamp":1763452172000},"page":"384-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical recommendations for early identification of patients with open\u2010angle glaucoma at higher risk of low adherence to topical treatment: An Italian Delphi consensus"],"prefix":"10.1111","volume":"104","author":[{"given":"Roberto G.","family":"Carassa","sequence":"first","affiliation":[{"name":"Centro Italiano Glaucoma  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pomponio","sequence":"additional","affiliation":[{"name":"Ospedali Riuniti di Ancona  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-6305","authenticated-orcid":false,"given":"Luca","family":"Agnifili","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences University \u201cG. d'Annunzio\u201d of Chieti\u2010Pescara  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-6054","authenticated-orcid":false,"given":"Antonio Maria","family":"Fea","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Iester","sequence":"additional","affiliation":[{"name":"Clinica Oculistica, Di.N.O.G.M.I. University of Genova, e IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Marchini","sequence":"additional","affiliation":[{"name":"Department of Surgical Odontostomatological Maternal and Child Sciences University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Martini","sequence":"additional","affiliation":[{"name":"U.O. Ophthalmology, Sassuolo Hospital  Sassuolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Miglior","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Policlinico di Monza Hospital University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-0004","authenticated-orcid":false,"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[{"name":"Glaucoma Unit, IRCCS Fondazione Bietti  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rossetti","sequence":"additional","affiliation":[{"name":"Eye Clinic and Head and Neck Department, ASST Santi Paolo e Carlo Hospital University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6399-3140","authenticated-orcid":false,"given":"Matteo","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Azienda Ospedaliero\u2010Universitaria di Sassari, Department of Medicine, Surgery and Pharmacy University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0510-6651","authenticated-orcid":false,"given":"Carlo Enrico","family":"Traverso","sequence":"additional","affiliation":[{"name":"Clinica Oculistica, University of Genova, Department Di.N.O.G.M.I. Italy Casa Della Salute  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-9033","authenticated-orcid":false,"given":"Michele","family":"Figus","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2023-egsguidelines"},{"key":"#cr-split#-e_1_2_7_3_1.1","unstructured":"Al\u2010Nuaimi D. Salam T.&Raj S.(2015)Side effects of eye drops on compliance: Patients' perspectives. Program and abstracts of the World Glaucoma Congress 2009"},{"key":"#cr-split#-e_1_2_7_3_1.2","unstructured":"Boston MA July 8-11 2009. Abstract P419.http:\/\/www.snlg\u2010iss.it\/cms\/files\/manuale_metodologico_consensus.pdf."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.07.015"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.03.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065636"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S439457"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14978"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.2351"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.13245"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38987.492014.94"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00780-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmu031"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12160-014-9641-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2024.2322048"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15725"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31821dac86"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191185"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.11.023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0290"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001965"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30425-3"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.83.5.711"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2019.1625405"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.015"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31818456b9"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2021.4415"},{"key":"e_1_2_7_28_1","first-page":"109","article-title":"Relationships among illness perceptions, medication beliefs and medication adherence in primary angle closure glaucoma patients","volume":"53","author":"Jiang H.","year":"2017","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2024.08.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1873947"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002227"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13463"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e31824cd0ae"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-011-9468-2"},{"key":"e_1_2_7_35_1","first-page":"655","article-title":"How to use the nominal group and Delphi techniques","volume":"38","author":"McMillan S.S.","year":"2016","journal-title":"International Journal of Clinical Pharmacy"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogla.2021.06.001"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00797-8"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2023.2279740"},{"key":"e_1_2_7_39_1","unstructured":"National Institutes of Health. (2009)Consensus Development Program. Available from:http:\/\/consensus.nih.gov\/ABOUTCDP.htm#intro."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.039"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.10.022"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.03.026"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03247-y"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-52800-2"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.213"},{"key":"e_1_2_7_46_1","article-title":"Ocular surface disease signs and symptoms of glaucoma patients and their relation to glaucoma medication in Finland","volume":"33","author":"Parkkari M.","year":"2022","journal-title":"European Journal of Ophthalmology"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000977"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11050635"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-023-00831-9"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2017.09.002"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_2008_20"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.10.038"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.06.012"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.5301\/EJO.2010.6112"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200522040-00004"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.02.009"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2015.10.013"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.337"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2020.26.3.325"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001943"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.05.013"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000574"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000301"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053805"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02646-3"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.06.024"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.103"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.11.026"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181f7b10e"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53376.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132897"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.13524"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T16:22:54Z","timestamp":1779034974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/aos.70024"],"URL":"https:\/\/doi.org\/10.1111\/aos.70024","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}