{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T17:06:35Z","timestamp":1779037595945,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010372","name":"Rotterdamse Stichting Blindenbelangen","doi-asserted-by":"publisher","award":["2023\u201022"],"award-info":[{"award-number":["2023\u201022"]}],"id":[{"id":"10.13039\/501100010372","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010318","name":"Landelijke Stichting voor Blinden en Slechtzienden","doi-asserted-by":"publisher","award":["2023\u201022"],"award-info":[{"award-number":["2023\u201022"]}],"id":[{"id":"10.13039\/501100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe the treatment rate for retinopathy of prematurity (ROP) at a tertiary referral neonatal intensive care unit (NICU) in the south\u2010western region of the Netherlands. In addition, we evaluated the impact of outsourcing laser treatment, implemented in 2018, by comparing treatment characteristics from 3\u2009years prior and 3\u2009years following this organisational change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational cohort study evaluated data of preterm infants born between 2015 and 2020 who were admitted to our NICU and met the eligibility criteria for ROP screening. ROP treatment rate was calculated for infants screened in our NICU. The impact of outsourcing laser treatment was evaluated based on ROP type at treatment decision, time between treatment decision and treatment, and adverse outcomes, including additional treatments and retinal detachment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 358 infants were screened at our NICU between 2015 and 2020; complete data were available for 343 infants, of whom 15% (51\/343) required treatment. Since outsourcing treatment, additional treatment secondary to laser was performed less frequently (25%, 5\/20 versus 7%, 2\/31). However, the mean number of days between treatment decision and treatment increased since outsourcing treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and 32% (9\/28) of cases were treated prior to reaching the criteria of type 1 ROP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The treatment rate among infants screened at our tertiary referral NICU exceeds previous national and hospital\u2010level reports, likely due to early transfer of low\u2010risk cases. Outsourcing ROP treatment might have led to improved primary treatment success; however, possible disadvantages include treatment delays and over\u2010treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70029","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:04:07Z","timestamp":1764086647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of retinopathy of prematurity in a tertiary referral neonatal intensive care unit: Treatment rates and the impact of outsourcing laser therapy"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-6965","authenticated-orcid":false,"given":"L. A.","family":"Derks","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Taal","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Neonatal and Paediatric Intensive Care Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-4076","authenticated-orcid":false,"given":"S. E.","family":"Loudon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. K. M.","family":"Reiss","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Neonatal and Paediatric Intensive Care Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Vingerling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Tjiam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Erasmus University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1371776"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_2_8_4_1","unstructured":"Centre de R\u00e9f\u00e9rence des Maladies Rares en Ophtalmologie (OPHTARA) H\u00f4pital Universitaire Necker Enfants Malades. (2023)Protocole National de Diagnostic et de Soins (PNDS): Prise en charge de la R\u00e9tinopathie du pr\u00e9matur\u00e9."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16045-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.04.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.11.9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2007.11.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.05.002"},{"key":"e_1_2_8_10_1","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good WV & Early Treatment for Retinopathy of Prematurity Cooperative Group","year":"2004","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.12.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.11.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2015-307263"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15751"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.117283"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2021.00773"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.04.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11010039"},{"key":"e_1_2_8_21_1","article-title":"Effect of centralization on surgical outcome of children operated for liver tumors in Switzerland: a retrospective comparative study","volume":"9","author":"Leoni J.","year":"2022","journal-title":"Children (Basel)"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12113650"},{"key":"e_1_2_8_23_1","unstructured":"Nederlands Oogheelkundig Gezelschap. (2013)Richtlijn prematuren retinopathie (ROP)."},{"key":"e_1_2_8_24_1","unstructured":"Perined. (2022)Peristat."},{"key":"e_1_2_8_25_1","unstructured":"Royal College of Ophthalmologists. (2022)Clinical guidelines \u2013 Treating retinopathy of prematurity in the UK."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-024-05842-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14406"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2023-061957"},{"key":"e_1_2_8_29_1","unstructured":"SWEDROP Styrgruppen. (2023)Nationella riktlinjer f\u00f6r screening och behandling av prematuritetsretinopati (ROP)."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517247"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-319929"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14501"},{"key":"e_1_2_8_33_1","unstructured":"T\u00fcrk Neonatoloji Derne\u011fi. (2021)T\u00fcrkiye Premat\u00fcre Retinopatisi Rehberi 2021 G\u00fcncellemesi."},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2022.10.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303123"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.015"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002965"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2012.01.007"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.10.023"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-27933-4"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70029","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T16:22:47Z","timestamp":1779034967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/aos.70029"],"URL":"https:\/\/doi.org\/10.1111\/aos.70029","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}