{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:46:18Z","timestamp":1787683578209,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 436 participants in two randomized controlled trials were analysed. Anterior chamber flare was measured in 69 participants undergoing trabeculectomy and 367 participants undergoing phacoemulsification preoperatively. Postoperative assessments were made on day 7 in trabeculectomy participants and on day 3 in phacoemulsification participants. CMT was assessed at baseline and 3\u2009months postoperatively in both groups and 4\u2009weeks postoperatively for trabeculectomy participants and 3\u2009weeks postoperatively for phacoemulsification participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, AC flare and CMT were comparable between the groups. Early postoperatively, AC flare was 22.1\u2009ph\/ms [95% CI 19.1, 25.7] for trabeculectomy and 18.9\u2009ph\/ms [95% CI 17.8, 20.2] for phacoemulsification. Both groups significantly increased in AC flare from their baseline values, but the difference in increase between them was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46). In the trabeculectomy group, CMT showed no significant increase at 4\u2009weeks but a significant rise of 2.3 microns from baseline to 3\u2009months from 241 microns [95% CI 235.9, 246.1] to 243.3 microns [95% CI 237.6, 249.1] (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). In the phacoemulsification group, CMT was significantly increased at 3\u2009weeks and remained significantly elevated at 3\u2009months from 242.6 microns [95% CI 240.4, 244.8] to 249.8 microns [95% CI 247.3, 252.4], increased by 7.2 microns (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). CMT increased significantly more after phacoemulsification compared to trabeculectomy at 3 to 4\u2009weeks (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and 3\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) with respect to baseline values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No significant difference in AC flare was found between trabeculectomy and phacoemulsification participants at baseline and early postoperatively. CMT did not increase at 4\u2009weeks but increased significantly at 3\u2009months after trabeculectomy. Phacoemulsification led to a significantly higher CMT increase at both 3\u2009weeks and 3\u2009months with respect to baseline compared to trabeculectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70032","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T04:27:02Z","timestamp":1763612822000},"page":"402-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Anterior chamber flare and central macular thickness after trabeculectomy versus after phacoemulsification"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5817-9247","authenticated-orcid":false,"given":"Yasmeen","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen 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