{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:02:05Z","timestamp":1790186525656,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate long\u2010term outcomes of anti\u2010VEGF therapy for nAMD using the Polish Retinal Therapeutic Program Monitoring Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The cohort consisted of 63\u2009840 eyes with nAMD qualified for treatment from 2016 to 2022, with follow\u2010up through 31 October 2023. Long\u2010term follow\u2010up (&gt;5\u2009years) was conducted for 7631 eyes. Statistical comparisons and multivariate logistic regression analysed differences between treatment failure and long\u2010term treatment, treatment effectiveness, drug efficacy and predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The relative risk of nAMD in females was 1.45. By the last follow\u2010up, 17\u2009518 (48.6%) patients discontinued treatment due to patient\u2010related factors, 7202 (20.0%) due to treatment failure, 6285 (17.4%) for other reasons and 5065 (14.0%) due to death or clinical complications. Long\u2010term patients were significantly younger, more of them were previously treated, received fewer injections per year and had better baseline BCVA and lower CRT than the failure group. Females and previously treated patients had a higher likelihood of long\u2010term therapy, while older age and initial ranibizumab treatment increased the risk of failure. Patients with an initial BCVA &gt;0.4 logMAR had significantly worse BCVA outcomes, while CRT and treatment strategy showed no significant differences. Introduction of programme exclusion if treatment gap &gt;4\u2009months reduced long breaks, increased injection numbers, slightly lowered BCVA and had no significant effect on CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early visual acuity response, drug choice (aflibercept), and healthcare system modifications influence long\u2010term success and adherence in nAMD management. While systemic changes improved continuity and injection frequency, they did not enhance visual outcomes, highlighting the need for individualized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70040","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:22:10Z","timestamp":1763367730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcomes of nationwide coordinated neovascular\n                    <scp>AMD<\/scp>\n                    treatment: A study based on Polish national registry"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-8880","authenticated-orcid":false,"given":"S\u0142awomir","family":"Teper","sequence":"first","affiliation":[{"name":"Chair and Clinical Department of Ophthalmology, Faculty of Medical Sciences in Zabrze Medical University of Silesia  Katowice 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