{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:15:46Z","timestamp":1783527346048,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271086"],"award-info":[{"award-number":["82271086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess associations of macular drusen in a general population, affected by age\u2010related macular degeneration (AMD) or free of any retinal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants of the population\u2010based cross\u2010sectional Beijing Eye Study underwent optical coherence tomography. Macular volume scans were assessed for macular drusen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 870 eyes (870 participants) (age: 64.7\u2009\u00b1\u20099.9\u2009years; range: 50\u201391\u2009years), randomly selected within the groups of early AMD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009356 (40.9%) eyes), intermediate AMD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009201; 23.1%), late AMD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096; 0.7%) and within eyes without AMD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009307; 35.3%). In multivariable analysis, higher drusen count was associated (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200925) with older age (beta: 0.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.048), higher serum concentration of cholesterol (beta: 0.10;\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u20090.008), shorter axial length (beta: \u22120.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), thicker subfoveal choroidal thickness (beta: 0.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), higher prevalences of macular hyperpigmentations (beta: 0.13;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), hyperreflective foci (HRFs) (beta: 0.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and reticular pseudodrusen (beta: 0.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and a lower prevalence of a visible Henle's layer (beta: \u22120.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Larger drusen size was associated with shorter axial length (beta: \u22120.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), thicker subfoveal choroidal thickness (beta: 0.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), higher prevalences of macular hypopigmentations (beta: 0.14;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and HRFs (beta: 0.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lower prevalences of a visible Henle's layer (beta: \u22120.19;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and of reticular pseudodrusen (beta: \u22120.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this population\u2010based study on Chinese, higher macular drusen count was associated with shorter axial length, thicker subfoveal choroidal thickness, higher prevalences of macular hyperpigmentations, HRFs and reticular pseudodrusen and lower prevalence of a visible Henle's layer. These findings may be clinically helpful and etiologically interesting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70043","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:35:44Z","timestamp":1764678944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of macular drusen in an East Asian population. 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