{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T17:06:35Z","timestamp":1779037595076,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study characterized and assessed vision\u2010related quality of life (VRQoL) in patients with neovascular age\u2010related macular degeneration (nAMD) who discontinued treatment with intravitreal anti\u2010vascular endothelial growth factor (anti\u2010VEGF), comparing them to those undergoing treatment. Secondarily, it explored reasons for treatment discontinuation against medical advice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This survey\u2010based cross\u2010sectional study used data collected for the Danish study, \u201cIdentification of Patient\u2010Reported Barriers in Treatment for nAMD\u201d (I\u2010OPTA) at Odense University Hospital, Denmark. I\u2010OPTA included a self\u2010developed questionnaire and the National Eye Institute Visual Function Questionnaire\u201025 (NEI\u2010VFQ\u201025). Main outcomes were demographics, treatment details, NEI\u2010VFQ\u201025 scores, and reasons for treatment discontinuation against medical advice. Linear regression models investigated the impact of variables on the composite NEI\u2010VFQ\u201025 score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 172 (32.6%) patients who had discontinued treatment and 356 (67.4%) patients who were undergoing treatment; 10 (5.8%) discontinued against medical advice. Discontinued patients were older (median 81.0\u2009years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.004), had lower best\u2010corrected visual acuity (BCVA) in the worse\u2010seeing eye (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value&lt;0.001), had a shorter treatment duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.001) and lived alone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.044). Discontinued patients showed lower scores in all NEI\u2010VFQ\u201025 domains except ocular pain. Higher BCVA correlated with a higher composite score of NEI\u2010VFQ\u201025. Reasons for discontinuation against medical advice included treatment burden and perceived inefficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients who discontinued treatment for nAMD report lower VRQoL, with lower BCVA in the worse\u2010seeing eye, older age, living alone, and unilateral treatment possibly contributing to treatment discontinuation. Future studies on visual acuity and retinal fluid in this group could guide decisions on treatment discontinuation, emphasizing patients' quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70044","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:10:10Z","timestamp":1765807810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing and assessing vision\u2010related quality of life among patients discontinued treatment for neovascular age\u2010related macular degeneration"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4811-1257","authenticated-orcid":false,"given":"Noreddin","family":"Shekho","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-7542","authenticated-orcid":false,"given":"Anna Stage","family":"Vergmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik N\u00f8rregaard","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lonny","family":"Stokholm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-3568","authenticated-orcid":false,"given":"Benjamin Sommer","family":"Thinggaard","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Agency for Digital Government. 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