{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T17:06:35Z","timestamp":1779037595048,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YF2502800"],"award-info":[{"award-number":["2022YF2502800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171100"],"award-info":[{"award-number":["82171100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752442"],"award-info":[{"award-number":["2024M752442"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the longitudinal change of choroidal thickness (ChT) and tessellated fundus progression in Chinese adults over 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this population\u2010based longitudinal cohort study, 1646 right eyes of 1646 participants were examined. Fundus photographs were obtained and ChT was measured using swept\u2010source optical coherence tomography. Participants were categorized into high\u2010myopia, low\u2010myopia, and non\u2010myopia groups, and the tessellated fundus was graded 0\u20133 based on the fundus photographs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean baseline age, refractive error, axial length (AL), and macular ChT were 62.51\u2009\u00b1\u20099.89\u2009years, \u22120.48\u2009\u00b1\u20093.18 D, 23.71\u2009\u00b1\u20091.58\u2009mm, and 199.7\u2009\u00b1\u200977.3\u2009\u03bcm, respectively. At the 4\u2010year follow\u2010up, a significant reduction in macular ChT of 4.05\u2009\u00b1\u20096.24, 4.44\u2009\u00b1\u20096.87, and 3.51\u2009\u00b1\u20095.17\u2009\u03bcm per year was observed in the non\u2010myopia, low\u2010myopia, and high\u2010myopia groups, respectively. Age, baseline ChT, and AL changes (with\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sup>non\u2010M<\/jats:sup>\n                      \u2009=\u2009\u221278.439,\n                      <jats:italic>\u03b2<\/jats:italic>\n                      <jats:sup>HM<\/jats:sup>\n                      \u2009=\u2009\u221256.505) were independently related to the rate of macular ChT change (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, the decrease in the ChT distribution pattern varied with different refractive groups. Moreover, 4.31% of the participants had tessellated fundus progression; these participants had more ChT reduction over 4\u2009years than those without tessellated fundus progression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Choroidal thinning was found to be associated with age and AL elongation. For every 1\u2009mm increase in AL, the decrease rate of ChT in the high\u2010myopia group was slower than that in the non\u2010myopia group. Progression of tessellated fundus was associated with a faster decrease in ChT, highlighting its potential as a biomarker for myopia progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70046","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:46:18Z","timestamp":1765201578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Four\u2010year longitudinal choroidal thickness changes and tessellated fundus progression in an eastern Chinese population"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-6150","authenticated-orcid":false,"given":"Menghan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"},{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7830-0167","authenticated-orcid":false,"given":"Luyao","family":"Ye","sequence":"additional","affiliation":[{"name":"The Affiliated People's Hospital of Ningbo University  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"},{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-6022","authenticated-orcid":false,"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4246-4343","authenticated-orcid":false,"given":"Xun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"},{"name":"Shanghai Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghuang","family":"He","sequence":"additional","affiliation":[{"name":"School of Optometry The Hong Kong Polytechnic University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-546X","authenticated-orcid":false,"given":"Jiangnan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital  Shanghai China"},{"name":"Department of Ophthalmology, Putuo People's Hospital, School of Medicine Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14826"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8076"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.01.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25957"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.07.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-321046"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-321295"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.12.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4383"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3325"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2016.05.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17480"},{"key":"e_1_2_8_17_1","volume-title":"Webvision: the organization of the retina and visual system","author":"Kolb H.","year":"1995"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12701"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.5.34"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25800"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316866"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12456"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0791-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.616249"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.12.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.09.004"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60272-4"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.5.3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.01.022"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.5.5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8046"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16446"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12862"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2018.10.005"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-15736"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13771"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-304000"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25965"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156842"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.9.26"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000466"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.4.14"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.2.34"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.01.003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-022-00276-4"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-020-04644-5"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29009-1"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.031"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15020"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103586"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10660-z"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T16:22:51Z","timestamp":1779034971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/aos.70046"],"URL":"https:\/\/doi.org\/10.1111\/aos.70046","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}