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Here, we explored if elevated systemic C\u2010reactive protein (\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    ), a marker of systemic low\u2010grade inflammation, is associated with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    . We systematically searched 12 literature databases on 12 April 2025 for studies in which blood\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    is measured in both patients with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    and a comparable control group. Studies were reviewed qualitatively. Meta\u2010analysis using the random\u2010effects model was performed on the weighted mean difference in systemic\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    levels between patients with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    and controls. Six studies comprising 544 patients with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    and 655 control individuals were eligible for this review. The meta\u2010analysis of the difference in\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    between patients with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    and controls showed no statistically significant difference at 0.86\u2009mg\/L (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : \u22121.03\u20132.75\u2009mg\/L;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.37). One study reported a very high degree of association between elevated\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    , which was not reproduced in the other studies. The lack of association remained consistent in the sensitivity analyses. Current evidence does not suggest that elevated systemic\n                    <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                    levels are associated with\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    . Further studies on\n                    <jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>\n                    pathophysiology are warranted.\n                  <\/jats:p>","DOI":"10.1111\/aos.70049","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T20:09:48Z","timestamp":1764619788000},"page":"476-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic C\u2010reactive protein levels and central serous chorioretinopathy: A systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"104","author":[{"given":"Vanessa S.","family":"Vimalasingam","sequence":"first","affiliation":[{"name":"Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Mit\u00d8je v\/Danske Speciall\u00e6ger ApS  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie S.","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Rigshospitalet  Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Anguita","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital, NHS Foundation Trust  London UK"},{"name":"Department of Ophthalmology, Inselspital University Hospital Bern, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse J.","family":"Cehofski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elon H. 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