{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:55:30Z","timestamp":1791561330698,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The TWO\u2010ROP algorithm is a modified screening protocol based on US data for low\u2010risk infants that limits screening to a single outpatient exam at 38 or 40\u2009weeks to reduce the retinopathy of prematurity (ROP) screening burden without compromising safety. The aim of this study was to validate the algorithm on an external data set outside the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective study of premature infants screened for ROP at a tertiary centre in Greece. Infants with higher birth weight (BW) and greater gestational age (GA) were included and stratified into three groups: group 1 (BW\u2009&lt;\u20091500\u2009g, GA\u2009\u2265\u200932\u2009weeks), group 2 (BW\u2009\u2265\u20091500\u2009g, GA\u2009&lt;\u200932\u2009weeks) and group 3 (BW\u2009\u2265\u20091500\u2009g, GA\u2009\u2265\u200932\u2009weeks). The rate of ROP and type 1 ROP were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five hundred and fifty\u2010three of the 1251 infants (44.2%) met the inclusion criteria. Groups 1, 2 and 3 had 139 (25.1%), 283 (51.2%) and 131 (23.7%) patients. Fourteen patients (2.5%) had ROP, including 7 in group 1, 7in group 2 and 0 in group 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No patient met the criteria for type 1 ROP. No cases of treatment warranted ROP (TW\u2010ROP) were observed in the cohort, indicating no missed cases under the TWO\u2010ROP algorithm. When applying the algorithm, 14.3%\u201314.9% (mean 14.6%) of ROP examinations were saved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TWO\u2010ROP algorithm can reduce examinations while ensuring safety in Greece when using the local screening guidelines. This is the first ex\u2010US validation and supports the potential for risk\u2010stratified screening globally to optimize resources while maintaining safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70053","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:10:13Z","timestamp":1764825013000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of the \u2018\n                    <scp>TWO<\/scp>\n                    \u2010\n                    <scp>ROP<\/scp>\n                    \u2019 algorithm in a tertiary Care Centre in Greece"],"prefix":"10.1111","volume":"104","author":[{"given":"Stella","family":"Moutzouri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Chaaya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Massachusetts Eye and Ear  Boston Massachusetts USA"},{"name":"Department of Ophthalmology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Altamirano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srujay","family":"Pandiri","sequence":"additional","affiliation":[{"name":"University of Missouri\u2010Kansas City School of Medicine  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3922-360X","authenticated-orcid":false,"given":"Sandra","family":"Hoyek","sequence":"additional","affiliation":[{"name":"Department of 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