{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:06:46Z","timestamp":1783854406655,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To analyse the frequency and type of coexisting systemic disorders in children operated on for cataract in Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were retrieved from the Swedish National Pediatric Cataract Register (PECARE) for children operated between January 1, 2007, and December 31, 2023 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009975), including follow\u2010ups at age 1, 2, 5\u2009and 10. Cataracts due to uveitis, trauma or radiation, and lens extraction due to luxation were excluded. Genetic screening was not mandatory during this period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 872 children who remained after exclusions, 466 (53.4%) had unilateral cataracts and 406 (46.6%) had bilateral cataracts. Coexisting systemic disorders were found in 132\/872 (15.1%), of which 5\/132 (3.8%) were strongly suspected, 64\/132 (48.5%) defined and 63\/132 (47.7%) undefined. Overall, 20\/872 (2.3%) were developmentally delayed without any systemic disorder diagnosis. Systemic disorder was present in 20\/466 (4.3%) with unilateral cataracts, 112\/406 (27.6%) with bilateral cataracts, 22\/138 (15.9%) with bilateral inherited cataracts and 11\/32 (34.4%) with parental consanguinity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Coexisting systemic disorders were present regardless of laterality, but more common among children with bilateral cataracts. Prevalence was similar among children with consanguineous parents, and lower among children with hereditary cataracts. National consensus regarding genetic screening for systemic disorders is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70054","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:25:27Z","timestamp":1765603527000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Swedish National Pediatric Cataract Register (\n                    <scp>PECARE<\/scp>\n                    ): Coexisting systemic disorders 2007\u20132023"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5750-0086","authenticated-orcid":false,"given":"David","family":"Wackerberg","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, V\u00e4stra G\u00f6talandsregionen Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-3352","authenticated-orcid":false,"given":"Jenny","family":"Gyll\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, V\u00e4stra G\u00f6talandsregionen Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte","family":"Haargaard","sequence":"additional","affiliation":[{"name":"Private Ophthalmologist  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alf","family":"Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, V\u00e4stra G\u00f6talandsregionen Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Karatepe Hashas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, V\u00e4stra G\u00f6talandsregionen Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Linnarsson Wiklund","sequence":"additional","affiliation":[{"name":"Department of Paediatric Ophthalmology and Strabismus St Erik Eye Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Trocm\u00e9","sequence":"additional","affiliation":[{"name":"Department of Paediatric Ophthalmology and Strabismus St Erik Eye Hospital  Stockholm Sweden"},{"name":"Division of Ophthalmology and Vision, Department of Clinical Neuroscience Karolinska 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