{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:06:47Z","timestamp":1783854407469,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Mesopic microperimetry (mMP) is a promising functional endpoint in clinical trials for Stargardt disease type 1 (STGD1). This study evaluated the test\u2013retest variability of mMP and influencing factors, which is essential for ensuring reliability in future STGD1 trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and fifteen eyes from 68 patients enrolled in the prospective, tertiary, multicentre STArgardt Remofuscin Treatment Trial (STARTT) underwent mMP testing using the macular integrity assessment (MAIA) microperimeter (CenterVue, Padova, Italy) at both the screening (first) and baseline (second) visits of the trial. Test\u2013retest variability was assessed using Bland\u2013Altman analyses and coefficients of repeatability (CoR). Retinal sensitivity metrics included\n                      <jats:italic>mean sensitivity<\/jats:italic>\n                      (\n                      <jats:italic>MS<\/jats:italic>\n                      ) and\n                      <jats:italic>pointwise sensitivity<\/jats:italic>\n                      (\n                      <jats:italic>PWS<\/jats:italic>\n                      ). Other factors including fixation stability, exam duration and learning effect were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>MS<\/jats:italic>\n                      demonstrated the lowest variability (CoR: 3.53\u2009dB, 95% CI: 3.07\u20133.99), while\n                      <jats:italic>PWS<\/jats:italic>\n                      exhibited the highest (CoR: 12.69\u2009dB, 95% CI: 12.47\u201312.91). Variability decreased in sensitivity ranges from \u22121 to 3\u2009dB and 16 to 32\u2009dB and from central to peripheral regions. Test duration (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.609,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and fixation losses (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.284,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) were significantly associated with increased variability. Other fixation stability metrics showed no correlation. No learning effect was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Given its high variability,\n                      <jats:italic>PWS<\/jats:italic>\n                      should be used cautiously.\n                      <jats:italic>MS<\/jats:italic>\n                      offers lower variability but may mask localised functional changes. A parafoveal ring strategy may improve reliability but requires validation. Limiting test duration to \u2264450\u2009seconds and comprehensive operator training are recommended to minimise potential bias.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70072","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:45:13Z","timestamp":1769687113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesopic microperimetry in Stargardt disease: Application and reliability"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3190-4156","authenticated-orcid":false,"given":"Sybren H.","family":"Kootstra","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Centre  Nijmegen GA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-6690","authenticated-orcid":false,"given":"Jeroen A. A. H.","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Centre  Nijmegen GA The Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behaviour Radboud University  Nijmegen EN The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-1668","authenticated-orcid":false,"given":"Patty P. A.","family":"Dhooge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Radboud University Medical Centre  Nijmegen GA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Schmitz\u2010Valckenberg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Bonn  Bonn Germany"},{"name":"John A. Moran Eye Centre University of Utah  Salt Lake City Utah USA"},{"name":"GRADE Reading Centre  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio Battaglia","family":"Parodi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ospedale San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Bonn  Bonn Germany"},{"name":"Centre for Rare Diseases Bonn (ZSEB) University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Bonn  Bonn Germany"},{"name":"GRADE Reading Centre  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lotery","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Stingl","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Centre for Ophthalmology University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Centre for Rare Eye Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Wheeler\u2010Schilling","sequence":"additional","affiliation":[{"name":"University Eye Hospital, Centre for Ophthalmology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-7932","authenticated-orcid":false,"given":"Camiel J. 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