{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:06:46Z","timestamp":1783854406653,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the impact of initial mono\u2010 versus multitherapy on the ocular surface and related quality of life after 5\u2009years follow\u2010up in the Glaucoma Intensive Treatment Study (GITS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study included patients with primary open\u2010angle glaucoma and pseudoexfoliation glaucoma who completed 5\u2010year follow\u2010up in GITS. Assessment of ocular surface disease (OSD) symptoms was done using a Swedish Translation of the OSD Index (OSDI). Signs of OSD were assessed with tear break\u2010up time (BUT), Schirmer I test and staining using Lissamine green. Rasch analysis was used to analyse OSDI results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data on OSD symptoms were available at 5\u2009years in 90% (219\/242) of all participants initially included in GITS. Subjective or objective OSD findings did not differ significantly between mono\u2010 and multitherapy. More than 90% of patients in both arms reported no or little subjective ocular surface problems and showed no or minimal staining with Lissamine green at the 60\u2010month visit. Furthermore, 46% had normal BUT and 60% normal Schirmer tests. Use of preservative\u2010free drops or need for additive lubricating tear drops did not differ between the arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found no differences in objective or subjective impact on ocular surface between the two randomization arms. However, a subgroup of glaucoma patients had more severe OSD irrespective of the amount of topical glaucoma treatment received, and this should be considered when choosing glaucoma therapy treatment in this subgroup by considering laser treatment or non\u2010preserved eye drops.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70078","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:29:46Z","timestamp":1769693386000},"page":"535-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of mono\u2010 or multitherapy on ocular surface health and quality of life after 5\u2009years of follow\u2010up in the Glaucoma Intensive Treatment Study (GITS)"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-4563","authenticated-orcid":false,"given":"Gauti","family":"J\u00f3hannesson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University  Ume\u00e5 Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institutet, St Eriks Eye Hospital  Stockholm Sweden"},{"name":"Department of Ophthalmology University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3597-4740","authenticated-orcid":false,"given":"Christina","family":"Lind\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Ophthalmology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Aspberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Lund University  Malm\u00f6 Sweden"},{"name":"Department of Ophthalmology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Andersson\u2010Geimer","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Lund University  Malm\u00f6 Sweden"},{"name":"Department of Ophthalmology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7233-6919","authenticated-orcid":false,"given":"Anders","family":"Heijl","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-3953","authenticated-orcid":false,"given":"Boel","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-2026","authenticated-orcid":false,"given":"Dorothea","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences in Malm\u00f6, Ophthalmology Lund University  Malm\u00f6 Sweden"},{"name":"Department of Ophthalmology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15130"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joco.2018.07.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.03.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.06.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13791"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200310000-00008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0048497"},{"key":"e_1_2_7_10_1","unstructured":"EGS. 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