{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:06:46Z","timestamp":1783854406236,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["20\u2010B\u20100169"],"award-info":[{"award-number":["20\u2010B\u20100169"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019562","name":"Synoptik-Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate changes in choroidal and retinal thickness before and during myopia control treatment with orthokeratology lenses (OKL) in myopic children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a sub\u2010study of CONTROL and CONTROL2 studies. The present study was a 2\u2010year, prospective, single\u2010group interventional study consisting of a 6\u2010month pre\u2010treatment observation period followed by 18\u2010month OKL treatment. Choroidal and retinal thicknesses were measured using a 3D macula scan with swept\u2010source optical coherence tomography. All thickness measures were corrected for magnification using the Imagenet6 software. Axial length was measured using Lenstar LS900 and corrected for change in central corneal thickness. Data were collected at three pre\u2010treatment visits and seven post\u2010treatment visits (from Day 3 up to 18\u2009months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 20 study participants had a mean age of 11.2\u2009\u00b1\u20091.9\u2009years, median cycloplegic spherical equivalent refractive error of \u22122.58 diopters (range\u2009\u2212\u20094.75 to \u22121.00) and mean axial length of 24.56\u2009\u00b1\u20090.63\u2009mm. During the pre\u2010treatment period, there was a statistically significant decrease in retinal thickness of \u22121.44\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038, SE 0.70, 95% CI \u20132.82 to \u22120.08), but a significant increase was seen after initiation of OKL treatment. Thickness peaked at 2.54\u2009\u03bcm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, SE 0.72, 95% CI 1.13 to 3.95) at the 6\u2010month follow\u2010up. We observed a tendency for the choroidal thickness to decrease during the pre\u2010treatment period (\u22125.96\u2009\u03bcm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.12, SE 3.78, 95% CI \u201313.37 to 1.46) and then a statistically significant increase after treatment initiation with a peak of 11.95\u2009\u03bcm after 1\u2009month of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003, SE 4.08, 95% CI 3.94 to 19.96). Short\u2010term change in choroidal thickness after treatment initiation did not correlate with change in overall eye length defined as subfoveal choroidal thickness plus axial length adjusted for post\u2010treatment change in central corneal thickness. For each individual participant, the choroidal thickness and retinal thickness were highly positively correlated at each visit throughout the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, 95% CI 0.69 to 2.09, linear mixed model).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with OKL increased both retinal and choroidal thickness in myopic children. Short\u2010term change in choroidal thickness was not a predictor for growth of the overall eye length. Further studies of the presumed structural changes in the choroid and the retina are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70084","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:23:37Z","timestamp":1769610217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in choroidal and retinal thickness 6 months before and during 18 months of orthokeratology lens treatment in myopic children"],"prefix":"10.1111","volume":"104","author":[{"given":"P. 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