{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:37:15Z","timestamp":1790289435860,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NEI P30\u2010 EY026877"],"award-info":[{"award-number":["NEI P30\u2010 EY026877"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n This study aims to evaluate the performance of the telemedicine retinopathy of prematurity severity score (tROP\u2010SS) across all 14 NICUs in the TELEROP cohort against the modified ROP activity score (mROP\u2010ActS).<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Subjects<\/jats:title>\n The study included 2037 neonates who underwent ROP screening in 14 NICUs via the TELEROP telemedicine network from November 2017 to January 2025.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We compared the robustness of tROP\u2010SS and mROP\u2010Act systems across all exams.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n The primary outcomes studied were the ability to return a score in cases responding to treatment, correlation between the two scores and the ability to assess disease directionality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The study analysed 192\u2009704 photos from 11\u2009368 ROP exams on 2037 patients. tROP\u2010SS generated scores for 100% of exams, demonstrating significant improvements over mROP\u2010ActS, which scored only 92.3% of all exams (\n p<\/jats:italic>\n =\u20090.0136). All patients who met treatment criteria received treatment in both eyes. Among high\u2010risk and treatment warranted (TW) patients, 100.0% exams had a valid tROP\u2010SS exam compared with only 72.73% and 45.27% with a valid mROP\u2010ActS. Only 20.9% high\u2010risk or TW patients had a valid mROP\u2010ActS across all their exams. Incremental increases in tROP\u2010SS were more strongly related to worsening of disease: OR (95% CI) \u2013 3.37 (2.51\u20134.53) versus 1.57 (1.46\u20131.69), both\n p<\/jats:italic>\n <\u20090.0001. tROP\u2010SS also demonstrated improved granularity and accuracy in categorizing patients that would ultimately require treatment (AUC: 0.991 vs. 0.825).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n tROP\u2010SS was retrospectively evaluated across 14 NICUs, proving to be a more robust scoring system compared to mROP\u2010ActS. The findings support continued use of tROP\u2010SS, supplemented by standard screening protocols to ensure no cases of treatment\u2010warranted ROP are missed. Future research may focus on integrating additional parameters to enhance predictive models to improve early ROP detection.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aos.70101","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:59:38Z","timestamp":1773025178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multi\u2010site performance of the telemedicine retinopathy of prematurity severity score (tROP\u2010SS)"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-1416","authenticated-orcid":false,"given":"Sarthak V.","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur R.","family":"Brant","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-2985","authenticated-orcid":false,"given":"Cindy","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Wood","sequence":"additional","affiliation":[{"name":"Austin Retina Associates Austin Texas USA"},{"name":"Department of Ophthalmology, Dell Medical School University of Texas Austin Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon D.","family":"Scarboro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dell Medical School University of Texas Austin Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Kumm","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2254-292X","authenticated-orcid":false,"given":"Darius M.","family":"Moshfeghi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Horngren Family Vitreoretinal Center, Byers Eye Institute, Stanford University School of Medicine Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.17461"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2020.04.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2021.00773"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2023.04.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20201223-03"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14532"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2023.10.003"},{"key":"e_1_2_5_10_1","first-page":"1","article-title":"A systematic review of economic evaluations conducted for interventions to screen, treat, and manage Retinopathy of Prematurity (ROP) in the United States, United Kingdom, and Canada","volume":"1","author":"Smith A.F.","year":"2022","journal-title":"Ophthalmic Epidemiology"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1978"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2016.1208560"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-42150-w"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T10:18:16Z","timestamp":1783851496000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aos.70101"],"URL":"https:\/\/doi.org\/10.1111\/aos.70101","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}