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Multimodal imaging was evaluated, and the available optical coherence tomography (OCT) scans were screened for SRF development in the fellow eye during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 213 confirmed cCSC cases, 74 (35%) had bilateral SRF at baseline. Among 102 patients with unilateral SRF that met all inclusion criteria, 7\/102 (7%) developed SRF in the fellow eye over a mean follow\u2010up of 20.4\u2009months. Retinal pigment epithelial (RPE) alterations in the fellow eye were present at baseline in 7\/7 (100%) who developed SRF, compared to 59\/95 (62%) in those who did not (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042). Subfoveal choroidal thickness (SFCT) was higher in the SRF\u2010developing group (482.3 vs. 365.9\u2009\u03bcm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.306), although not significantly. Hyperautofluorescence on fundus autofluorescence (FAF) at baseline occurred in 6\/7 (86%) of the SRF\u2010developing group versus 25\/91 (28%) who did not (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). The ellipsoid zone was interrupted in 5\/7 (71%) of SRF\u2010developing patients versus 28\/95 (30%) who did not develop SRF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The risk of SRF development in the fellow eye of cCSC patients with unilateral SRF is relatively low over a follow\u2010up period of almost 2\u2009years. No statistically significant risk factors were identified after correction for multiple testing; however, certain trends were observed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70103","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:10:22Z","timestamp":1770894622000},"page":"666-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk factors for the development of subretinal fluid in the fellow eyes of patients with chronic central serous chorioretinopathy"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3106-0455","authenticated-orcid":false,"given":"Helena M. A.","family":"Feenstra","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Cakar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-8199","authenticated-orcid":false,"given":"Joost","family":"Brinks","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-7932","authenticated-orcid":false,"given":"Camiel J. 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