{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T17:00:47Z","timestamp":1786467647859,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To identify associations between systemic drugs and cataract surgery in Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs. Study population consisted of 106\u2009127 individuals aged \u226550\u2009years without diabetes originating from the 1996\u20132017 Fin\u2010CARING population. We constructed a nested case\u2013control study design comparing 17\u2009811 cases undergoing cataract surgery to 76\u2009532 age\u2010, sex\u2010 and hospital district\u2010matched controls without cataract surgery. Results are reported as odds ratios (ORs) with 95% confidence intervals (CIs) based on conditional logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Use of ramipril (1.14; 1.04\u20131.25), losartan (1.20; 1.07\u20131.35), bisoprolol (1.24; 1.18\u20131.31), amlodipine (1.16; 1.07\u20131.25), diltiazem (1.26; 1.06\u20131.49), isosorbide mononitrate (1.56; 1.44\u20131.70), furosemide (1.31; 1.18\u20131.45), simvastatin (1.17; 1.11\u20131.24), atorvastatin (1.17; 1.06\u20131.29), prednisolone (2.00; 1.64\u20132.42), allopurinol (1.47; 1.24\u20131.75), pramipexole (1.45; 1.13\u20131.86), testosterone (1.62; 1.03\u20132.55), estradiol (1.13; 1.03\u20131.24), oxazepam (1.26; 1.07\u20131.47), sertraline (1.74; 1.13\u20132.67) and zopiclone (1.31; 1.20\u20131.43) showed some evidence for an association with cataract surgery. Use of memantine (OR 0.24; 0.15\u20130.40), risperidone (0.72; 0.51\u20131.00), rivastigmine (0.35; 0.21\u20130.58) and donepezil (0.55; 0.40\u20130.76) was associated with a lower risk of cataract surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our large nested case\u2013control study suggests that certain systemic medications may increase the incidence of surgically treated cataract, but with the possibility of residual confounding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70118","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:56:08Z","timestamp":1773230168000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic medications associate with surgically treated cataract among adults over 50\u2009years in Finland"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2160-9168","authenticated-orcid":false,"given":"Antti","family":"Riikonen","sequence":"first","affiliation":[{"name":"Unit of Vitreoretinal Surgery, Department of Ophthalmology Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1450-6208","authenticated-orcid":false,"given":"Jari","family":"Haukka","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Lilius","sequence":"additional","affiliation":[{"name":"Individualized Drug Therapy Research Program University of Helsinki  Helsinki Finland"},{"name":"Department of Emergency Medicine and Services HUS Helsinki University Hospital and University of Helsinki  Helsinki Finland"},{"name":"Division of Pharmacology 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