{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:55:02Z","timestamp":1791561302666,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008485","name":"Schweizerische Akademie der Medizinischen Wissenschaften","doi-asserted-by":"publisher","award":["YTCR 43\/23"],"award-info":[{"award-number":["YTCR 43\/23"]}],"id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["323530_199395"],"award-info":[{"award-number":["323530_199395"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To measure the progression of geographic atrophy (GA) in subjects with age\u2010related macular degeneration (AMD) in a natural history study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed fundus autofluorescence (FAF) images using a semiautomatic method (RegionFinder) to quantify the GA area in a monocentric study. Three independent graders analysed each eye. Patient visits were scheduled at baseline, 12, 24 and 48\u2009weeks. The primary endpoint was the progression of GA area per eye. Potential correlations with clinical and imaging\u2010based parameters were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The annual GA progression rate was 1.16\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      \/year (95% CI: 0.76\u20131.56;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with faster growth in eyes with larger baseline lesions (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.74). After square root transformation, the progression rate was 0.34\u2009mm\/year (95% CI: 0.26\u20130.43;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and the size dependency was reduced (adjusted\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.16). Multivariable mixed\u2010effects models identified a significant association between larger GA lesion sizes per eye and the number of smoking pack\u2010years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), the presence of perilesional hyperautofluorescence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and a multifocal configuration of the GA lesions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038). Intermediate AMD in the fellow eye was significantly associated with faster GA progression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GA progression in AMD is significantly influenced by baseline lesion size and a larger number of smoking pack\u2010years is associated with larger GA lesions. The marked variability between individuals underscores the multifactorial nature of GA dynamics. Quantitative FAF analysis is a reliable method for assessing lesion progression and may inform risk\u2010based monitoring strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70119","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:38:24Z","timestamp":1772995104000},"page":"750-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The optical coherence tomography and microperimetry biomarker evaluation in patients with geographic atrophy (\n                    <scp>OMEGA<\/scp>\n                    ) study: Geographic atrophy progression in fundus autofluorescence \u2010\n                    <scp>OMEGA<\/scp>\n                    report 3"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-5630","authenticated-orcid":false,"given":"Philippe","family":"Valmaggia","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"},{"name":"Department of Biomedical Engineering University of Basel  Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4693-2061","authenticated-orcid":false,"given":"Georg","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Inglin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Basel  Allschwil Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7218-1659","authenticated-orcid":false,"given":"Nils","family":"Sch\u00e4rer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB)  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0849-4976","authenticated-orcid":false,"given":"Hanna","family":"Zuche","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7710-6671","authenticated-orcid":false,"given":"Chrysoula","family":"Gabrani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB)  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faady","family":"Yahya","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8431","authenticated-orcid":false,"given":"Marco","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB)  Basel Switzerland"},{"name":"Department of Clinical Research University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3642-3502","authenticated-orcid":false,"given":"Kristina","family":"Pfau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giani","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieh","family":"Esmaeelpour","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taffeta Chingning","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim International GmbH  Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8405-8933","authenticated-orcid":false,"given":"Christian","family":"Pr\u00fcnte","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital Basel  Basel Switzerland"},{"name":"Institute of Molecular and Clinical Ophthalmology Basel (IOB)  Basel Switzerland"},{"name":"Vue Eye Center  Biel\/Bienne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-0316","authenticated-orcid":false,"given":"Hendrik P. 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