{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:54:52Z","timestamp":1791561292284,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare the anatomic, functional and safety outcomes of intra\u2010operative 360\u2010degree prophylactic laser retinopexy versus focal laser retinopexy during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) and to assess the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Web of Science and Scopus were searched on June 27, 2025. Randomized controlled trials and comparative observational studies evaluating 360\u2010degree versus focal laser during PPV for RRD were included. Two reviewers independently extracted data and assessed risk of bias (ROB\u20102, NIH tools). Pooled analyses were conducted using random\u2010effects models, and the certainty of evidence was graded using GRADE. The primary outcome was single\u2010surgery anatomic success (SSAS). Secondary outcomes included best\u2010corrected visual acuity (BCVA), intraocular pressure (IOP) and post\u2010operative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen studies comprising 3639 eyes were included. Compared with focal laser, 360\u2010degree laser achieved higher odds of SSAS (OR: 1.82; 95% CI, 1.40\u20132.39;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%; moderate\u2010certainty). No differences were observed in final BCVA (MD\u2009=\u20090.06; 95% CI, \u22120.01 to 0.13;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200975.5%) or BCVA improvement (MD: \u20130.06; 95% CI, \u22120.22 to 0.11;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%). Rates of epiretinal membrane (OR\u2009=\u20091.11; 95% CI: 0.80\u20131.54,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200926.85%, moderate certainty), proliferative vitreoretinopathy (OR\u2009=\u20090.62; 95% CI: 0.36\u20131.08,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090%, moderate certainty), cystoid macular oedema and macular hole were comparable between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive 360\u2010degree laser retinopexy during PPV for RRD was associated with higher SSAS without a measurable increase in post\u2010operative complications. However, no improvement in visual acuity outcomes was observed. Given the predominance of observational evidence, further well\u2010designed randomized trials are warranted to clarify the magnitude of benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70127","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:00:40Z","timestamp":1775484040000},"page":"731-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three hundred sixty\u2010degree prophylactic laser retinopexy versus focal laser during rhegmatogenous retinal detachment repair: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4434-8335","authenticated-orcid":false,"given":"Luke","family":"Yaldo","sequence":"first","affiliation":[{"name":"Miller School of Medicine University of Miami  Miami Florida 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