{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:55:02Z","timestamp":1791561302777,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271086"],"award-info":[{"award-number":["82271086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess prevalence and associations of intra\u2010vitreal hyper\u2010reflective bodies (vHRBs) in the posterior vitreous in a general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants of the population\u2010based Beijing Eye Study underwent systemic and ophthalmological examinations. We included into this study a randomly selected group of normal eyes without retinal diseases and a randomly selected group of eyes with age\u2010related macular degeneration (AMD), polypoidal choroidal vasculopathy (PVC) or central serous choroidopathy (CSC). Using serial optical coherence tomography scans of the posterior fundus region, we searched for vHRBs in the posterior vitreous compartment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study consisted of 1347 eyes (age: 64.3\u2009\u00b1\u20099.8\u2009years, range: 50\u201391\u2009years; axial length: 23.04\u2009\u00b1\u20091.00\u2009mm, range: 19.39\u201328.93\u2009mm). vHRB were detected in 314\/1347 eyes (23.3%; 95% confidence interval [CI]: 21.1, 25.6), that is, in 137 out of 447 normal eyes (28.9%; 95% CI: 24.8, 33.0), 110\/458 eyes with early AMD (24.0%; 95% CI: 20.1, 27.9), 45\/278 eyes with intermediate AMD (16.2%; 95% CI: 11.8, 20.5), 3\/35 eyes with PCV (8.6%; 95% CI: 0.00, 18.3), and in 19\/94 eyes with CSC (20.2%; 95% CI: 11.9, 28.5). In multivariable analysis, higher vHRB prevalence was associated with younger age (OR: 0.93; 95% CI: 0.91, 0.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), shorter axial length (OR: 0.69; 95% CI:0.56, 0.84;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and lower stage of posterior vitreous detachment (OR: 0.53; 95% CI: 0.44, 0.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). It was independent of AMD stage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.87), and prevalence of PCV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.67) and CSC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.40). Higher amount of vHRBs (multivariable linear regression analysis) correlated with younger age (beta: \u22120.21; B: \u22120.02; 95% CI: \u22120.03, \u22120.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), shorter axial length (beta: \u22120.07; B: \u22120.09; 95% CI: \u22120.16, \u22120.02;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and lower stage of posterior vitreous detachment (beta: \u22120.15; B: \u22120.13; 95% CI: \u22120.19, \u22120.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>vHRBs were detected in one out of four normal eyes of individuals aged 50+ years, in dependence on younger age, shorter axial length and lower degree of posterior vitreous detachment. They were independent of a concurrence of AMD, PCV and CSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70139","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:25:53Z","timestamp":1776345953000},"page":"769-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and associations of hyper\u2010reflective bodies in the posterior vitreous: The Beijing eye study"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost B.","family":"Jonas","sequence":"first","affiliation":[{"name":"Rothschild Foundation Hospital, Institut Fran\u00e7ais de Myopie  Paris France"},{"name":"Singapore Eye Research Institute Singapore National Eye Center  Singapore"},{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine Tsinghua University  Beijing China"},{"name":"L V Prasad Eye Institute, L V Prasad Marg  Hyderabad Telangana India"},{"name":"Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong  Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"Rothschild Foundation Hospital, Institut Fran\u00e7ais de Myopie  Paris France"},{"name":"L V Prasad Eye Institute, L V Prasad Marg  Hyderabad Telangana India"},{"name":"Privatpraxis Prof Jonas Und Dr. Panda\u2010Jonas  Heidelberg Germany"},{"name":"Department of Ophthalmology University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-3047","authenticated-orcid":false,"given":"Rahul A.","family":"Jonas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine University of Cologne, University Hospital Cologne  Cologne Germany"},{"name":"Institute of Ophthalmology University College London  UK"},{"name":"Moorfields Eye Hospital NHS Foundation Trust  London UK"},{"name":"NIHR Moorfields Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Xing","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, Tsinghua Medicine Tsinghua University  Beijing China"},{"name":"Beijing Institute of Ophthalmology Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University  Beijing 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