{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:48:16Z","timestamp":1782193696214,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Baerveldt glaucoma drainage implant (BGI 101\u2013350) is one of the most effective treatment options for managing refractory glaucoma. To mitigate early hypotony in non\u2010valved implants, intraluminal occluding sutures (IOSs) are commonly used. This study compares the swelling behavior of two widely used IOSs: 3\u20130 nylon (Supramid Extra) and 3\u20130 polypropylene (Prolene). Long\u2010term clinical outcomes associated with each suture material are also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective randomised interventional study was conducted involving 94 patients undergoing BGI 101\u2013350 implantation, divided into two groups: Supramid (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948) and Prolene (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). An experimental swelling model using confocal microscopy and ImageJ software quantified the hygroscopic behavior of each suture material by determining the intraluminal gaps area before and after wetting. Postoperative intraocular pressure (IOP), medication use and removal timing were analyzed over 60\u2009months using independent\u2010samples\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, while categorical variables, including hypotony rates and the need for suture adjustment, were compared using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The experimental model demonstrated ~60% swelling in Supramid vs. ~3% in Prolene IOS. Clinically, both groups achieved comparable IOP control at 6, 12 and 60\u2009months (mean IOP at 60\u2009months: Supramid 11\u2009\u00b1\u20091.75\u2009mmHg, Prolene 11\u2009\u00b1\u20091.37\u2009mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The Prolene group required markedly fewer postoperative interventions: no suture adjustments compared with 10 in the Supramid group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and suture removal occurred significantly later (mean 8.9 vs. 4.96\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Transient hypotony following suture removal occurred in 6.25% of Supramid cases and in none with Prolene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>3\u20130 Prolene offers better predictability and repeatability, earlier IOP control, delayed and safer suture removal and reduced need for early interventions while maintaining equivalent long\u2010term IOP control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70174","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T05:27:36Z","timestamp":1782192456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective randomised comparison of two different stenting sutures when using the Baerveldt 101\u2013350 aqueous shunt \u2013 Lab transition to clinical process"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-7983","authenticated-orcid":false,"given":"Evripidis","family":"Sykakis","sequence":"first","affiliation":[{"name":"Department of Anterior Segment &amp; Glaucoma Eye Day Clinic  Athens Greece"},{"name":"Emmetropia Mediterranean Eye Institute  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4102-6242","authenticated-orcid":false,"given":"Anastasia","family":"Tsiogka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Evgenideio Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Selimis","sequence":"additional","affiliation":[{"name":"Emmetropia Mediterranean Eye Institute  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minas I.","family":"Aslanides","sequence":"additional","affiliation":[{"name":"Emmetropia Mediterranean Eye Institute  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-1627","authenticated-orcid":false,"given":"Athanasios","family":"Skouras","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences University of Patras  Patras Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kenanakis","sequence":"additional","affiliation":[{"name":"Institute of Electronic Structure and Laser Foundation for Research &amp; Technology\u2010Hellas  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis M.","family":"Aslanides","sequence":"additional","affiliation":[{"name":"Emmetropia Mediterranean Eye Institute  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6718-3804","authenticated-orcid":false,"given":"Minas M.","family":"Stylianakis","sequence":"additional","affiliation":[{"name":"Institute of Electronic Structure and Laser Foundation for Research &amp; Technology\u2010Hellas  Heraklion Greece"},{"name":"Department of Nursing, School of Health Sciences Hellenic Mediterranean University  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.07.015"},{"key":"e_1_2_6_3_1","first-page":"67","article-title":"Fluid absorption and capillarity of suture materials","volume":"143","author":"Blomstedt B.","year":"1977","journal-title":"Acta Chirurgica 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