{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:46:30Z","timestamp":1782222390603,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The increasing number of patients with diabetes has increased the incidence of diabetic macular oedema (DME) with the accompanying risk of developing visual loss. The purpose of the present study was to describe the contributions of increased central retinal thickness (CRT) and other risk factors to the reduction in visual acuity in patients diagnosed with treatment\u2010requiring DME.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Best corrected visual acuity (BCVA) in the better eye was correlated with CRT at the last examination before treatment of 582 patients with DME between 2011 and 2024. Multiple linear regression was used to evaluate the contributions of CRT, sex, age, diabetes duration, body mass index (BMI) and mean arterial blood pressure (MAP) to the variation in BCVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BCVA was significantly inversely correlated with CRT, with an average reduction of one ETDRS letter per 17.9 micrometres increase in CRT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and CRT could explain approximately 32% of the variation in BCVA. In a multivariate model, increased CRT, higher age and female sex contributed independently to a lower BCVA, whereas diabetes duration, BMI and MAP showed no significant contribution to the variation in BCVA. The inclusion of all the variables could explain approximately 41% of the variation in BCVA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In DME, BCVA is on average reduced by 1 ETDRS letter for each 17.9 micrometres increase in CRT. However, BCVA in DME is also reduced by higher age and female sex.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70177","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:46:52Z","timestamp":1782218812000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visual acuity is reduced with increasing central retinal thickness, but also with higher age and female sex in diabetic macular oedema"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-2631","authenticated-orcid":false,"given":"Signe Krejberg","family":"Jeppesen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-2534","authenticated-orcid":false,"given":"Toke","family":"Bek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Aarhus University Hospital  Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00417-020-04640-9","article-title":"Spectral domain optical coherence tomography classification of diabetic macular edema: a new proposal to clinical practice","volume":"258","author":"Arf S.","year":"2020","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"issue":"3","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/24741264231165611","article-title":"Association between contrast sensitivity and central subfield thickness in center\u2010involving diabetic macular edema","volume":"7","author":"Baldwin G.","year":"2023","journal-title":"J Vitreoretin Dis"},{"issue":"8","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1080\/02713683.2020.1712729","article-title":"Incidence and risk for developing proliferative diabetic retinopathy after photocoagulation for diabetic maculopathy","volume":"45","author":"Bek T.","year":"2020","journal-title":"Current Eye Research"},{"issue":"11","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1007\/s00125-020-05234-0","article-title":"Systemic risk factors contribute differently to the development of proliferative diabetic retinopathy and clinically significant macular oedema","volume":"63","author":"Bek T.","year":"2020","journal-title":"Diabetologia"},{"issue":"6","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/aos.16637","article-title":"Individualised screening for diabetic retinopathy with proliferative diabetic retinopathy and macular oedema as separate end points","volume":"102","author":"Bek T.","year":"2024","journal-title":"Acta Ophthalmologica"},{"issue":"5","key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/aos.15641","article-title":"Visual acuity and causes of central visual loss in the adult Danish population 2020\u20132022. 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