{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:20:25Z","timestamp":1783095625418,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Retinal telangiectatic capillaries (TelCaps) are microvascular abnormalities associated with chronic vascular macular oedema and suboptimal response to intravitreal therapy. Targeted laser photocoagulation is beneficial but requires precise localization using indocyanine green angiography (ICG\u2010A), the reference standard. However, ICG\u2010A is invasive and not easily repeatable. This study evaluated OCT performance for TelCaps identification and en face localization versus ICG\u2010A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ICG\u2010A and OCT images from 62 patients with TelCaps secondary to diabetic retinopathy or vein occlusion were analysed in a masked fashion. TelCaps were identified on OCT cube B\u2010scans using predefined structural criteria and subsequently localized on co\u2010registered infrared en face images. Sensitivity, positive predictive value (PPV) and subgroup analyses were used to assess OCT accuracy for lesion localization versus ICG\u2010A and to evaluate the influence of anatomical factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ICG\u2010A identified 148 TelCaps, whereas OCT detected 157 lesions. ICG\u2010stained TelCaps appeared as isolated large lesions or clustered microvascular abnormalities. OCT\u2010identified and en face localized lesions showed 87% sensitivity (95% CI, 81%\u201392%) and 82% PPV (95% CI, 75%\u201388%). Sensitivity was higher for isolated lesions (92%) and those adjacent to hard exudates, but lower for clustered lesions (62%) and those distant from exudates. False positives were mainly lesions without retinal thickening or exudates, while false negatives predominantly involved clustered lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OCT represents a valuable non\u2010invasive tool for identifying and localizing TelCaps on en face images in eyes with macular oedema and hard exudates, supporting its use for guiding focal laser photocoagulation. While it may reduce the need for systematic ICG\u2010A in selected patients, angiography remains essential in complex equivocal cases, particularly for clustered lesions, where OCT may be less effective.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70182","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:37:03Z","timestamp":1783093023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["En face localization of retinal telangiectatic capillaries using\n                    <scp>OCT<\/scp>\n                    compared with\n                    <scp>ICG<\/scp>\n                    angiography in chronic vascular macular oedema"],"prefix":"10.1111","author":[{"given":"Lucas","family":"Unger","sequence":"first","affiliation":[{"name":"Univ Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Dupas","sequence":"additional","affiliation":[{"name":"COSS\u2010 Centre Ophtalmologique Sorbonne St Michel  Paris France"},{"name":"Department of Ophthalmology, Hopital Lariboisiere, APHP Universit\u00e9 Paris Cite  Paris France"},{"name":"FRCRNet\/FCRIN Network  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bennani","sequence":"additional","affiliation":[{"name":"Clinique Rachidi  Casablanca Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Castro Farias","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National Des Quinze\u2010Vingts  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Girmens","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National Des Quinze\u2010Vingts  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Couturier","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hopital Lariboisiere, APHP Universit\u00e9 Paris Cite  Paris France"},{"name":"FRCRNet\/FCRIN Network  France"},{"name":"Department of Ophthalmology, Retina Service Adolphe De Rothschild Foundation Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Paques","sequence":"additional","affiliation":[{"name":"FRCRNet\/FCRIN Network  France"},{"name":"Centre Hospitalier National Des Quinze\u2010Vingts  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010No\u00eblle","family":"Delyfer","sequence":"additional","affiliation":[{"name":"Univ Bordeaux, INSERM, BPH, U1219  Bordeaux France"},{"name":"Service d'Ophtalmologie Centre Hospitalier Universitaire de Bordeaux  Bordeaux France"},{"name":"FRCRNet\/FCRIN Network  France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00417-009-1175-6","article-title":"Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography","volume":"248","author":"Bourhis A.","year":"2010","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"4","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/bjophthalmol-2019-314355","article-title":"Indocyanine green angiography for identifying telangiectatic capillaries in diabetic macular oedema","volume":"104","author":"Castro Far\u00edas D.","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"e_1_2_7_4_1","first-page":"2501","article-title":"Screening of telangiectatic capillaries in chronic macular edema based on multimodal imaging: a study of 101 eyes. LyoMAC1 study","volume":"260","author":"Chaperon M.","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/s41598-022-05950-0","article-title":"Intraprocedural OCT monitoring of the immediate treatment response during indocyanine green angiography\u2010guided laser therapy of teleangiectatic capillaries in diabetic macular edema","volume":"12","author":"Datlinger F.","year":"2022","journal-title":"Sci Rep"},{"issue":"2","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/24741264221149295","article-title":"Telangiectatic capillaries in retinal vascular occlusions: multimodal imaging in a case series","volume":"7","author":"De Oliveira M.R.V.","year":"2023","journal-title":"Journal of Vitreoretinal 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