{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:52:45Z","timestamp":1782219165641,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011831","name":"De Blindas V\u00e4nner","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["2024.0253"],"award-info":[{"award-number":["2024.0253"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["KAW 2018.0310"],"award-info":[{"award-number":["KAW 2018.0310"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010810","name":"\u00d6gonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Dexamethasone eye drops are being introduced off\u2010label to prevent progression of severe retinopathy of prematurity (ROP). We evaluated ophthalmologic outcomes in early childhood after postnatal topical dexamethasone exposure in pre\u2010term infants at a standardized follow\u2010up examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cross\u2010sectional follow\u2010up study included preterm infants born between 2019 and 2022 in the V\u00e4stra G\u00f6taland region, Sweden, who received topical dexamethasone off\u2010label during ROP screening. As a follow\u2010up, a single standardized ophthalmological examination assessed visual acuity, refractive error, ocular motility, intraocular pressure (IOP) and structural ocular abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four infants (median gestational age 25.0\u2009weeks, range 22.6\u201327.7\u2009weeks; 58% male) were examined at a median age of 2.9\u2009years (range 1.1\u20135.0\u2009years). Dexamethasone eye drops were initiated mainly for severe ROP at a median postmenstrual age of 35.1\u2009weeks (range 32.0\u201352.0\u2009weeks) and given for a median duration of 28\u2009days (range 4\u2013136\u2009days). Median IOP was 18.9\u2009mmHg (range 9.0\u201322.3\u2009mmHg), and no child showed clinical signs of glaucoma. One child had a unilateral peripheral lens opacity without visual significance. No other ocular structural abnormalities were detected. Strabismus was detected in 2 (8%) of the children, and 3 (12%) had refractive errors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preliminary data from extremely preterm infants exposed to off\u2010label topical dexamethasone during ROP screening showed no clinically significant ocular adverse effects at standardized early childhood follow\u2010up. Rates of strabismus and refractive errors were lower than expected. Larger studies with longer follow\u2010up are needed to further assess ocular and systemic safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70189","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:17:44Z","timestamp":1782217064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Childhood ocular safety after postnatal exposure to topical dexamethasone during retinopathy of prematurity screening"],"prefix":"10.1111","author":[{"given":"Mariya","family":"Petrishka\u2010Lozenska","sequence":"first","affiliation":[{"name":"The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Ophthalmology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-0783","authenticated-orcid":false,"given":"Anders K.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-1244","authenticated-orcid":false,"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Ophthalmology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7731-1988","authenticated-orcid":false,"given":"Pia","family":"Lundgren","sequence":"additional","affiliation":[{"name":"The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Ophthalmology Sahlgrenska University Hospital, Region V\u00e4stra G\u00f6taland  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"The trabecular meshwork: a basic review of form and function","volume":"2","author":"Abu\u2010Hassan D.W.","year":"2014","journal-title":"Journal of Ocular 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