{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:52:35Z","timestamp":1782301955859,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine the prevalence of dome\u2010shaped macula (DSM) in high myopia (HM) and to compare the clinical characteristics of eyes with and without DSM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, longitudinal, single\u2010centre cohort study included patients with HM, with or without DSM. Baseline demographic and clinical characteristics were collected. Multimodal imaging was performed at baseline and during follow\u2010up to assess the presence of macular neovascularization (MNV) and serous retinal detachment (SRD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1133 eyes of 619 HM patients (67% of women; mean [standard deviation] age: 48.9 [16.9] years) were analyzed. The eye\u2010level and patient\u2010level prevalences of DSM were 15% (173\/1133 eyes) and 19% (117\/619 patients), respectively. Compared to non\u2010DSM eyes, DSM eyes showed a longer axial length (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), a worse baseline visual acuity (VA) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and a higher prevalence of diffuse chorioretinal atrophy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). The longitudinal analysis was limited to DSM eyes, with a mean follow\u2010up of 28.0 (44.2) months. At the final visit, MNV was found in 47 eyes (27%) and SRD in 10 eyes (6%). MNV incidence was 4.02 (95% confidence interval [CI]: 1.79\u20136.70) per 100 eye\u2010years. The presence of SRD at baseline was associated with a greater dome height (odds ratio\u2009=\u20091.007;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Vitreoretinal interface abnormalities were more frequently observed in eyes with lower dome height.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DSM was detected in approximately 15% of HM eyes. Patients with DSM showed a worse baseline VA compared to those without DSM. MNV was the most common and vision\u2010threatening complication, while SRD was relatively uncommon, occurring only in cases of significant bulging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70191","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:42:34Z","timestamp":1782301354000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dome\u2010shaped macula in high myopia: Prevalence and clinical characteristics in a French cohort"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2632-8560","authenticated-orcid":false,"given":"Sebastiano","family":"Del Fabbro","sequence":"first","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"},{"name":"Department of Ophthalmology Paris Cit\u00e9 University, Lariboisi\u00e8re University Hospital, APHP  Paris France"},{"name":"Retina Department Foundation Adolphe de Rothschild Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Philippakis","sequence":"additional","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"},{"name":"Department of Ophthalmology Paris Cit\u00e9 University, Lariboisi\u00e8re University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1638","authenticated-orcid":false,"given":"Matteo Maria","family":"Carl\u00e0","sequence":"additional","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"},{"name":"Department of Ophthalmology Paris Cit\u00e9 University, Lariboisi\u00e8re University Hospital, APHP  Paris France"},{"name":"Retina Department Foundation Adolphe de Rothschild Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhomitra","family":"Panda\u2010Jonas","sequence":"additional","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-5227","authenticated-orcid":false,"given":"Jost","family":"Jonas","sequence":"additional","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Gaudric","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Paris Cit\u00e9 University, Lariboisi\u00e8re University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Couturier","sequence":"additional","affiliation":[{"name":"French Myopia Institute, Foundation Adolphe de Rothschild Hospital  Paris France"},{"name":"Department of Ophthalmology Paris Cit\u00e9 University, Lariboisi\u00e8re University Hospital, APHP  Paris France"},{"name":"Retina Department Foundation Adolphe de Rothschild Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archopht.1993.01090090052019","article-title":"Laser photocoagulation of Subfoveal Neovascular lesions of age\u2010related macular degeneration","volume":"111","year":"1993","journal-title":"Archives of Ophthalmology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.ajo.2013.06.032","article-title":"Morphologic characterization of dome\u2010shaped macula in myopic eyes with serous macular detachment","volume":"156","author":"Caillaux V.","year":"2013","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2025.09.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/sj.eye.6701934","article-title":"Prevalence of blindness and low vision in an Italian population: a comparison with other European studies","volume":"20","author":"Cedrone C.","year":"2006","journal-title":"Eye"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.ophtha.2014.06.012","article-title":"Visual acuity outcome in RADIANCE study patients with dome\u2010shaped macular features","volume":"121","author":"Ceklic L.","year":"2014","journal-title":"Ophthalmology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jfo.2013.10.002","article-title":"\u00c9paisseur choro\u00efdienne fov\u00e9olaire au SD\u2010OCT dans la myopie forte avec macula bomb\u00e9e","volume":"37","author":"Chebil A.","year":"2014","journal-title":"Journal Fran\u00e7ais d'Ophtalmologie"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.oret.2022.12.002","article-title":"Incidence and risk factors of visual impairment in patients with Angioid streaks and macular neovascularization","volume":"7","author":"Cicinelli M.V.","year":"2023","journal-title":"Ophthalmology Retina"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ajo.2025.01.011","article-title":"Agreement between color, fluorescein angiography, and spectral domain optical coherence tomography in the detection of macular fibrosis in Neovascular age\u2010related macular degeneration","volume":"272","author":"Csincsik L.","year":"2025","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri S.","year":"2019","journal-title":"Saudi Journal of Anaesthesia"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.14.8.9","article-title":"Dome\u2010shaped macula curvature: a new quantitative metric to assess dome\u2010shaped macula subtypes","volume":"14","author":"Del Fabbro S.","year":"2025","journal-title":"Translational Vision Science & Technology"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jcjo.2025.07.007","article-title":"Visual outcomes, incidence and risk factors for RPE atrophy in myopic patients with dome\u2010shaped macula and serous retinal detachment","volume":"61","author":"Del Fabbro S.","year":"2026","journal-title":"Canadian Journal of Ophthalmology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajoc.2026.102537","article-title":"Progressive development of dome\u2010shaped macula and subsequent onset of punctate inner choroidopathy in a highly myopic patient: a 7\u2009year follow\u2010up case report","volume":"42","author":"Del Fabbro S.","year":"2026","journal-title":"Am J Ophthalmol Case Rep"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.ophtha.2013.07.042","article-title":"The international Vitreomacular traction study group classification of Vitreomacular adhesion, traction, and macular hole","volume":"120","author":"Duker J.S.","year":"2013","journal-title":"Ophthalmology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ajo.2012.08.007","article-title":"Three\u2010dimensional tomographic features of dome\u2010shaped macula by swept\u2010source optical coherence tomography","volume":"155","author":"Ellabban A.A.","year":"2013","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.61.3.19","article-title":"The morphological relationship between dome\u2010shaped macula and myopic Retinoschisis: a cross\u2010sectional study of 409 highly myopic eyes","volume":"61","author":"Fang D.","year":"2020","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178998","article-title":"Macular Bruch's membrane defect and dome\u2010shaped macula in high myopia","volume":"12","author":"Fang Y.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"M20","DOI":"10.1167\/iovs.18-25957","article-title":"IMI \u2013 defining and classifying myopia: a proposed set of standards for clinical and epidemiologic studies","volume":"60","author":"Flitcroft D.I.","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ajo.2008.01.012","article-title":"Dome\u2010shaped macula in eyes with myopic posterior staphyloma","volume":"145","author":"Gaucher D.","year":"2008","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.oret.2019.04.023","article-title":"Association between axial length and myopic maculopathy","volume":"3","author":"Hashimoto S.","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden B.A.","year":"2016","journal-title":"Ophthalmology"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1097\/IAE.0000000000003906","article-title":"Ten\u2010year longitudinal morphological changes in dome\u2010shaped maculas in highly myopic eyes","volume":"43","author":"Hsu C.\u2010R.","year":"2023","journal-title":"Retina"},{"key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ajo.2010.08.014","article-title":"Enhanced depth imaging optical coherence tomography of the sclera in dome\u2010shaped macula","volume":"151","author":"Imamura Y.","year":"2011","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1038\/s41433-021-01518-w","article-title":"Dome\u2010shaped maculopathy: a review","volume":"35","author":"Jain M.","year":"2021","journal-title":"Eye (London, England)"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101156","article-title":"Myopia: histology, clinical features, and potential implications for the etiology of axial elongation","volume":"96","author":"Jonas J.B.","year":"2023","journal-title":"Progress in Retinal and Eye Research"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2025.101402"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.survophthal.2020.11.002","article-title":"Dome\u2010shaped macula\u2014review of literature","volume":"66","author":"Kumar V.","year":"2021","journal-title":"Survey of Ophthalmology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/bjophthalmol-2019-314619","article-title":"Longitudinal changes in axial length in high myopia: a 4\u2010year prospective study","volume":"104","author":"Lee M.W.","year":"2020","journal-title":"British Journal of Ophthalmology"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.ophtha.2015.04.012","article-title":"Comparison of clinical features in highly myopic eyes with and without a dome\u2010shaped macula","volume":"122","author":"Liang I.\u2010C.","year":"2015","journal-title":"Ophthalmology"},{"key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1136\/bjophthalmol-2018-312780","article-title":"Spectrum of choroidal neovascularisation associated with dome\u2010shaped macula","volume":"103","author":"Marchese A.","year":"2019","journal-title":"British Journal of Ophthalmology"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"e963","DOI":"10.1111\/aos.14659","article-title":"A novel excel sheet conversion tool from Snellen fraction to LogMAR including \u2018counting fingers\u2019, \u2018hand movement\u2019, \u2018light perception\u2019 and \u2018no light perception\u2019 and focused review of literature of low visual acuity reference values","volume":"99","author":"Moussa G.","year":"2021","journal-title":"Acta Ophthalmologica"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1038\/s41433-025-03782-6","article-title":"Axial length as a predictor of myopic macular degeneration: a meta\u2010analysis and clinical study","volume":"39","author":"Mu T.","year":"2025","journal-title":"Eye"},{"issue":"9","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/iovs.63.9.28","article-title":"Quantification and predictors of OCT\u2010based macular curvature and dome\u2010shaped configuration: results from the UK biobank","volume":"63","author":"M\u00fcller P.L.","year":"2022","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajo.2015.01.022","article-title":"International photographic classification and grading system for myopic maculopathy","volume":"159","author":"Ohno\u2010Matsui K.","year":"2015","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajo.2014.02.054","article-title":"Morphologic characteristics of macular complications of a dome\u2010shaped macula determined by swept\u2010source optical coherence tomography","volume":"158","author":"Ohsugi H.","year":"2014","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age\u2010related macular degeneration on OCT","volume":"125","author":"Sadda S.R.","year":"2018","journal-title":"Ophthalmology"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ajo.2013.06.031","article-title":"Natural course of myopic traction maculopathy and factors associated with progression or resolution","volume":"156","author":"Shimada N.","year":"2013","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_38_1","first-page":"944","article-title":"Long\u2010term evolution of dome\u2010shaped macula","volume":"36","author":"Soudier G.","year":"2016","journal-title":"Retina"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000504051","article-title":"Serous retinal detachment in dome\u2010shaped macula is associated with greater central choroidal blood flow measured by optical coherence tomography angiography","volume":"243","author":"Soudier G.","year":"2020","journal-title":"Ophthalmologica"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1001\/jamaophthalmol.2016.4009","article-title":"Association of Axial Length with Risk of uncorrectable visual impairment for Europeans with myopia","volume":"134","author":"Tideman J.W.L.","year":"2016","journal-title":"JAMA Ophthalmol"},{"key":"e_1_2_9_41_1","first-page":"715","article-title":"The Hong Kong vision study: a pilot assessment of visual impairment in adults","volume":"95","author":"Van Newkirk M.R.","year":"1997","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ajo.2014.09.026","article-title":"Choroidal findings in dome\u2010shaped macula in highly myopic eyes: a longitudinal study","volume":"159","author":"Viola F.","year":"2015","journal-title":"American Journal of Ophthalmology"},{"key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/IAE.0000000000002168","article-title":"Clinical features of lacquer cracks in eyes with pathologic myopia","volume":"39","author":"Xu X.","year":"2019","journal-title":"Retina"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.survophthal.2023.07.006","article-title":"Pathogenesis of myopic choroidal neovascularization: a systematic review and meta\u2010analysis","volume":"68","author":"Zhang X.J.","year":"2023","journal-title":"Survey of Ophthalmology"},{"key":"e_1_2_9_45_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-021887","article-title":"Observational study of clinical characteristics of dome\u2010shaped macula in Chinese Han with high myopia at Zhongshan ophthalmic Centre","volume":"8","author":"Zhao X.","year":"2018","journal-title":"BMJ Open"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:42:39Z","timestamp":1782301359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":44,"alternative-id":["10.1111\/aos.70191"],"URL":"https:\/\/doi.org\/10.1111\/aos.70191","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"assertion":[{"value":"2026-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"aos.70191"}}