{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:04:00Z","timestamp":1785171840156,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop THESS\u2010ROP, a novel prediction model for treatment\u2010warranted retinopathy of prematurity (TW\u2010ROP) and compare its performance with four established models in a Greek cohort of consecutively screened preterm infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This ambispective cohort study included all 526 infants screened for ROP (2016\u20132022) at the 2nd Neonatology Department of Aristotle University of Thessaloniki, a tertiary neonatal intensive care unit in Greece. The primary outcome was TW\u2010ROP (type 1 or 2 or aggressive ROP). Secondary outcomes included type 1 ROP and ROP treatment. A penalized ridge logistic regression model was developed using gestational age, birth weight, sepsis, and hydrocephalus up to 4\u2009weeks postnatal age. Missing data were addressed using 10\u2010fold multiple imputation. Internal validation used bootstrap resampling with optimism correction. External validation of CO\u2010ROP, G\u2010ROP, G\u2010ROP 180\u2009g, and ROPScore was performed in the same cohort. Performance was assessed using area under the curve (AUC), sensitivity, specificity, positive predictive value, and negative predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TW\u2010ROP developed in 34 infants (6.5%; 24 type 1, 10 type 2), with 29 receiving treatment. THESS\u2010ROP demonstrated excellent discrimination [optimism\u2010corrected AUC 0.935, 95% CI (0.905\u20130.965)], pooled sensitivity 98.0% and pooled specificity 58.0%. Sensitivity reached 100% for type 1 ROP and treated ROP. In external validation, CO\u2010ROP, G\u2010ROP, G\u2010ROP 180\u2009g, and ROPScore achieved pooled sensitivities of 90.9%, 98.8%, 98.8%, and 100.0% with specificities of 63.4%, 34.4%, 26.1%, and 62.1%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>THESS\u2010ROP model, incorporating easily available clinical data, enables effective early risk stratification at 4\u2009weeks PNA and may optimize ROP screening. External validation in independent populations is required before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70203","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:17:26Z","timestamp":1785169046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>THESS<\/scp>\n                    \u2010\n                    <scp>ROP<\/scp>\n                    study: Development of a prediction model for treatment\u2010warranted retinopathy of prematurity and external validation of postnatal weight\u2010gain\u2010based models in Greece"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-2133","authenticated-orcid":false,"given":"Stella","family":"Moutzouri","sequence":"first","affiliation":[{"name":"2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Bettina","family":"Haidich","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Social\u2010Preventive Medicine &amp; Medical Statistics, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lithoxopoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Neonatology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Pappas","sequence":"additional","affiliation":[{"name":"2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Tsakalidis","sequence":"additional","affiliation":[{"name":"2nd Department of Neonatology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Ziakas","sequence":"additional","affiliation":[{"name":"2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4238-022X","authenticated-orcid":false,"given":"Asimina","family":"Mataftsi","sequence":"additional","affiliation":[{"name":"2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.2753"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2019.4517"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2012.2524"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2016.01.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2015.10.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.05.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010078378"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.334"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102369\u20106690"},{"key":"e_1_2_8_13_1","first-page":"233","article-title":"Final results of the early treatment for retinopathy of prematurity (ETROP) randomized trial","volume":"102","author":"Good W.V.","year":"2004","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-19425-7","volume-title":"Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis","author":"Harrell F.E.","year":"2015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008\u20102697"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017512"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2025.12.021"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16622"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2023.100417"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/09286586.2025.2463069"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12113650"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.70188"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372\u2010021\u201001196\u20102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.16788"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13117"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.2336"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14532"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m441"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7992"},{"key":"e_1_2_8_30_1","volume-title":"Multiple imputation for nonresponse in surveys. 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