{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:10:25Z","timestamp":1785420625400,"version":"3.56.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\u20100333"],"award-info":[{"award-number":["P3\u20100333"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\u20100396"],"award-info":[{"award-number":["P3\u20100396"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["I0\u20100029"],"award-info":[{"award-number":["I0\u20100029"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["J3\u201060062"],"award-info":[{"award-number":["J3\u201060062"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["SN ZRD\/22\u201027\/0552"],"award-info":[{"award-number":["SN ZRD\/22\u201027\/0552"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["SN 707\u20100189"],"award-info":[{"award-number":["SN 707\u20100189"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Ophthalmologica"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels implicated in Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signalling across various tissues, yet their functional role in human lens epithelial cells remains poorly understood. We aimed to investigate the contribution of TRPV4 to mechanically induced Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signalling in human anterior lens epithelium.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Human anterior lens epithelial preparations were obtained from postoperative lens capsules, including both cataractous and non\u2010cataractous samples. Using multicellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      imaging, we analysed the spatiotemporal properties of intercellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      waves following localised mechanical stimulation under control conditions and after pharmacological inhibition of TRPV4 with HC\u2010067047.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mechanical stimulation triggered radially propagating Ca\n                      <jats:sup>2+<\/jats:sup>\n                      waves characterised by distance\u2010dependent attenuation of amplitude and kinetics. TRPV4 inhibition significantly reduced wave propagation velocity and enhanced spatial signal decay, indicating a key role in maintaining efficient intercellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signal propagation. These effects were most pronounced in non\u2010cataractous epithelium, while in cataractous lenses, they exhibited stage\u2010dependent differences, suggesting remodelling of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signalling pathways during disease progression. The observed intercellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      wave propagation is consistent with gap junctional and paracrine signalling, while TRPV4 activity modulates its efficiency by shaping the initiating Ca\n                      <jats:sup>2+<\/jats:sup>\n                      response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      TRPV4 channels contribute to both the efficiency and spatial extent of Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signalling in the lens epithelium. These findings identify TRPV4 as an important regulator of mechanically induced intercellular communication and a potential target for modulating lens function in health and disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aos.70208","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:26Z","timestamp":1785418586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPV4 channel\u2010mediated calcium signalling in human lens epithelium of cataract patients and healthy lens capsules"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-0485","authenticated-orcid":false,"given":"Marko","family":"Gosak","sequence":"first","affiliation":[{"name":"Faculty of Natural Sciences and Mathematics University of Maribor  Maribor Slovenia"},{"name":"Faculty of Medicine University of Maribor  Maribor Slovenia"},{"name":"Alma Mater Europaea University  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u0161a","family":"\u0160arman","sequence":"additional","affiliation":[{"name":"Eye Hospital, University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernarda","family":"Kinkela","sequence":"additional","affiliation":[{"name":"Eye Hospital, University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taja Vita","family":"Petrovi\u0107","sequence":"additional","affiliation":[{"name":"Eye Hospital, University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Me\u0161trovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Hawlina","sequence":"additional","affiliation":[{"name":"Eye Hospital, University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-728X","authenticated-orcid":false,"given":"Sofija","family":"Andjelic","sequence":"additional","affiliation":[{"name":"Eye Hospital, University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.exer.2013.01.009","article-title":"Intercellular Ca2+ wave propagation in human retinal pigment epithelium cells induced by mechanical stimulation","volume":"108","author":"Abu Khamidakh A.E.","year":"2013","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_3_1","first-page":"123","article-title":"Downregulation of TRPV4 and LRRC8A in crystalline lenses of diabetic patients may contribute to cataractogenesis","volume":"19","author":"Albert\u2010Garay J.S.","year":"2025","journal-title":"Clinical Ophthalmology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1111\/aos.12902","article-title":"Anterior lens epithelial cells attachment to the basal lamina","volume":"94","author":"Andjelic S.","year":"2016","journal-title":"Acta Ophthalmologica"},{"key":"e_1_2_8_5_1","first-page":"123","article-title":"Anterior lens capsule as a tool to study the physiology of human lens epithelial cells","volume":"79","author":"Andjelic S.","year":"2010","journal-title":"Zdravni\u0161ki Vestnik"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.febslet.2013.12.024","article-title":"Roles and regulation of lens epithelial cell connexins","volume":"588","author":"Berthoud V.M.","year":"2014","journal-title":"FEBS Letters"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.108.2.595","article-title":"Antisera directed against connexin 43 peptides react with a 43\u2010kD protein localized to gap junctions in myocardium and other tissues","volume":"108","author":"Beyer E.C.","year":"1989","journal-title":"The Journal of Cell Biology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1126\/science.1411526","article-title":"Intercellular propagation of calcium waves mediated by inositol trisphosphate","volume":"258","author":"Boitano S.","year":"1992","journal-title":"Science"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1113\/JP285194","article-title":"Endothelial TRPV4\u2010Cx43 signalling complex regulates vasomotor tone in resistance arteries","volume":"603","author":"Burboa P.C.","year":"2025","journal-title":"Journal of Physiology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1167\/iovs.19-27794","article-title":"The ciliary muscle and Zonules of Zinn modulate lens intracellular hydrostatic pressure through transient receptor potential Vanilloid channels","volume":"60","author":"Chen Y.","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1167\/iovs.66.15.37","article-title":"Regional differences in calcium dynamics in the intact lens: the role of TRPV channels in lens calcium regulation","volume":"66","author":"Chen Y.","year":"2025","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1242\/jcs.109.2.355","article-title":"Mechanical stimulation initiates cell\u2010to\u2010cell calcium signaling in ovine lens epithelial cells","volume":"109","author":"Churchill G.C.","year":"1996","journal-title":"Journal of Cell Science"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1242\/jcs.111.9.1217","article-title":"Roles of Ca2\u0163, inositol trisphosphate and cyclic ADPribose in mediating intercellular Ca2\u0163 signaling in sheep lens cells","volume":"111","author":"Churchill G.C.","year":"1998","journal-title":"Journal of Cell Science"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"C972","DOI":"10.1152\/ajpcell.2001.281.3.C972","article-title":"Ca(2+) regulation of gap junctional coupling in lens epithelial cells","volume":"281","author":"Churchill G.C.","year":"2001","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","article-title":"The lens opacities classification system III. The longitudinal study of cataract study group","volume":"111","author":"Chylack L.T.","year":"1993","journal-title":"Archives of Ophthalmology"},{"key":"e_1_2_8_16_1","first-page":"2355","article-title":"Regional differences in functional receptor distribution and calcium mobilization in the intact human lens","volume":"42","author":"Collison D.J.","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.biocel.2016.07.012","article-title":"Modulation of TRPV4 by diverse mechanisms","volume":"78","author":"Darby W.G.","year":"2016","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1089\/jop.2016.0054","article-title":"The significance of TRPV4 channels and hemichannels in the lens and ciliary epithelium","volume":"32","author":"Delamere N.A.","year":"2016","journal-title":"Journal of Ocular Pharmacology and Therapeutics"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.834916","article-title":"Ion transport regulation by TRPV4 and TRPV1 in lens and ciliary epithelium","volume":"12","author":"Delamere N.A.","year":"2022","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1101498","article-title":"Patch clamp studies on TRPV4\u2010dependent hemichannel activation in lens epithelium","volume":"14","author":"Ek\u2010Vitorin J.F.","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30\u2009years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study","volume":"9","author":"GBD 2019 Blindness and Vision Impairment Collaborators","year":"2021","journal-title":"The Lancet Global Health"},{"key":"e_1_2_8_22_1","article-title":"Cataract progression associated with modifications in calcium signaling in human lens epithelia as studied by mechanical stimulation","volume":"11","author":"Gosak M.","year":"2021","journal-title":"Life (Basel)"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143781","article-title":"The analysis of intracellular and intercellular calcium signaling in human anterior lens capsule epithelial cells with regard to different types and stages of the cataract","volume":"10","author":"Gosak M.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_8_24_1","first-page":"1250","article-title":"Causative and preventive action of calcium in cataracto\u2010genesis","volume":"25","author":"Gupta P.D.","year":"2004","journal-title":"Acta Pharmacologica Sinica"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1111\/bph.14762","article-title":"Endothelial TRPV4 channels modulate vascular tone by Ca2+ \u2212induced Ca2+ release at inositol 1,4,5\u2010trisphosphate receptors","volume":"176","author":"Heathcote H.R.","year":"2019","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_8_26_1","first-page":"638","volume-title":"Histology of the human eye","author":"Hogan M.J.","year":"1971"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021179","article-title":"The multifaceted functions of TRPV4 and calcium oscillations in tissue repair","volume":"25","author":"Jiang D.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2025.149338","article-title":"Crosstalk between signaling pathways (rho\/ROCK, TGF\u2010\u03b2 and WNT\/\u03b2\u2010catenin pathways\/PI3K\u2010AKT\u2010mTOR) in cataract: a mechanistic exploration and therapeutic strategy","volume":"947","author":"Khan M.","year":"2025","journal-title":"Gene"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1113\/jphysiol.1987.sp016848","article-title":"Optical recording of electrical activity from parallel fibres and other cell types in skate cerebellar slices in\u00a0vitro","volume":"393","author":"Konnerth A.","year":"1987","journal-title":"The Journal of Physiology"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.61.4.2","article-title":"Polymodal sensory transduction in mouse corneal epithelial cells","volume":"61","author":"Lapajne L.","year":"2020","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00029.2011","article-title":"Intercellular Ca2+ waves: mechanisms and function","volume":"92","author":"Leybaert L.","year":"2012","journal-title":"Physiological Reviews"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101112","article-title":"The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens","volume":"92","author":"Liu Z.","year":"2023","journal-title":"Progress in Retinal and Eye Research"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.21037\/atm-2019-rcs-03","article-title":"Lens regeneration in humans: using regenerative potential for tissue repairing","volume":"8","author":"Liu Z.","year":"2020","journal-title":"Annals of Translational Medicine"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exer.2015.01.012","article-title":"Calcium entry via connexin hemichannels in lens epithelium","volume":"132","author":"Mandal A.","year":"2015","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_35_1","doi-asserted-by":"crossref","first-page":"21257","DOI":"10.1074\/jbc.M109.020206","article-title":"The TRPV4 cation channel mediates stretch\u2010evoked Ca2+ influx and ATP release in primary urothelial cell cultures","volume":"284","author":"Mochizuki T.","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"e_1_2_8_36_1","first-page":"E3225","article-title":"UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin\u20101 signaling","volume":"110","author":"Moore C.","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_8_37_1","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1038\/s41467-023-39346-z","article-title":"Structure of human TRPV4 in complex with GTPase RhoA","volume":"14","author":"Nadezhdin K.D.","year":"2023","journal-title":"Nature Communications"},{"key":"e_1_2_8_38_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107707","article-title":"Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens","volume":"186","author":"Nakazawa Y.","year":"2019","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_39_1","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.00365.2003","article-title":"TRPV4 calcium entry channel: a paradigm for gating diversity","volume":"286","author":"Nilius B.","year":"2004","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00424-005-1424-4","article-title":"The mechanosensitive nature of TRPV channels","volume":"451","author":"O'Neil R.G.","year":"2005","journal-title":"Pfl\u00fcgers Archiv"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/978-94-007-2888-2_34","article-title":"Regulation of intercellular calcium signaling through calcium interactions with connexin\u2010based channels","volume":"740","author":"Orellana J.A.","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"e_1_2_8_42_1","volume-title":"The human eye: structure and function","author":"Oyster C.W.","year":"1999"},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1113\/JP275052","article-title":"Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells","volume":"595","author":"Phuong T.T.T.","year":"2017","journal-title":"The Journal of Physiology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.exer.2008.10.025","article-title":"The mechanisms of calcium homeostasis and signalling in the lens","volume":"88","author":"Rhodes J.D.","year":"2009","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_45_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113837","article-title":"TRPV4: a physio and Pathophysiologically significant Ion Channel","volume":"21","author":"Rosenbaum T.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"15689","DOI":"10.1523\/JNEUROSCI.2540-14.2014","article-title":"Swelling and eicosanoid metabolites differentially gate TRPV4 channels in retinal neurons and glia","volume":"34","author":"Ryskamp D.A.","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"e_1_2_8_47_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.exer.2014.08.009","article-title":"Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, M\u00fcller cells, lens, trabecular meshwork, cornea and lacrimal gland","volume":"127","author":"Sanderson J.","year":"2014","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"C1751","DOI":"10.1152\/ajpcell.00010.2012","article-title":"TRPV4 in porcine lens epithelium regulates hemichannel\u2010mediated ATP release and Na\u2010K\u2010ATPase activity","volume":"302","author":"Shahidullah M.","year":"2012","journal-title":"American Journal of Physiology. Cell Physiology"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2015.08.013","article-title":"Damage to lens fiber cells causes TRPV4\u2010dependent Src family kinase activation in the epithelium","volume":"140","author":"Shahidullah M.","year":"2015","journal-title":"Experimental Eye Research"},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41374-019-0362-2","article-title":"TRPV4 activation by thermal and mechanical stimuli in disease progression","volume":"100","author":"Shibasaki K.","year":"2020","journal-title":"Laboratory Investigation"},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.66.14.39","article-title":"Gap junctional versus paracrine signaling in the human lens epithelium: analysis based on multicellular Ca2+ imaging and computational modeling","volume":"66","author":"\u0160terk M.","year":"2025","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_52_1","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.1523\/JNEUROSCI.1249-20.2020","article-title":"Mechanosensory signaling in astrocytes","volume":"40","author":"Turovsky E.A.","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"e_1_2_8_53_1","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1038\/s41433-024-02961-1","article-title":"Global estimates on the number of people blind or visually impaired by cataract: a meta\u2010analysis from 2000 to 2020","volume":"38","author":"Vision Loss Expert Group","year":"2024","journal-title":"Eye (London, England)"},{"key":"e_1_2_8_54_1","doi-asserted-by":"crossref","first-page":"33704","DOI":"10.1074\/jbc.M204828200","article-title":"Molecular determinants of permeation through the cation channel TRPV4","volume":"277","author":"Voets T.","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: molecular conductor of a diverse orchestra","volume":"96","author":"White J.P.","year":"2016","journal-title":"Physiological Reviews"},{"key":"e_1_2_8_56_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/dev.114.1.203","article-title":"Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis","volume":"114","author":"Yancey S.B.","year":"1992","journal-title":"Development"},{"key":"e_1_2_8_57_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/19336950.2020.1803552","article-title":"Gap junctions amplify TRPV4 activation\u2010initiated cell injury via modification of intracellular Ca2+ and Ca2+\u2010dependent regulation of TXNIP","volume":"14","author":"Zhang X.","year":"2020","journal-title":"Channels (Austin, Tex.)"}],"container-title":["Acta Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aos.70208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aos.70208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:33Z","timestamp":1785418593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aos.70208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":56,"alternative-id":["10.1111\/aos.70208"],"URL":"https:\/\/doi.org\/10.1111\/aos.70208","archive":["Portico"],"relation":{},"ISSN":["1755-375X","1755-3768"],"issn-type":[{"value":"1755-375X","type":"print"},{"value":"1755-3768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"2026-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"aos.70208"}}